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370698 GW7647 - CAS 265129-71-3 - Calbiochem

A cell-permeable urea-substituted thioisobutyric acid compound that acts as a potent and selective PPARα.

GW7647 - CAS 265129-71-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: GW647, 2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid, PPAR Agonist IV, PPARα Agonist II, PPARβ/δ Agonist I, PPARγ Agonist III

Primary Target: PPARα
370698
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
265129-71-3C₂₉H₄₆N₂O₃S

Products

RéférenceConditionnement Qté
370698-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARα agonist (PPARα, γ and δ - EC50 = 6 nM, 1.1 µM and 6.2 µM for human; 1 nM, 1.3 µM and 2.9 µM for murine, respectively). Also displays in vivo lipid-lowering activity in rats.
Catalogue Number370698
Brand Family Calbiochem®
SynonymsGW647, 2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid, PPAR Agonist IV, PPARα Agonist II, PPARβ/δ Agonist I, PPARγ Agonist III
References
ReferencesMuoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089.
Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225.
Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306.
Poirier, H., et al. 2001. Biochem. J. 355, 481.
Product Information
CAS number265129-71-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₄₆N₂O₃S
Chemical formulaC₂₉H₄₆N₂O₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPPARα
Primary Target IC<sub>50</sub>EC50 = 6 nM, 1.1 µM and 6.2 µM for human PPARα, γ and δ, respectively; EC50 = 1 nM, 1.3 µM and 2.9 µM for murine PPARα, γ and δ, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
370698-5MG 04055977191769

Documentation

GW7647 - CAS 265129-71-3 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

GW7647 - CAS 265129-71-3 - Calbiochem Certificats d'analyse

TitreNuméro de lot
370698

Références bibliographiques

Aperçu de la référence bibliographique
Muoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089.
Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225.
Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306.
Poirier, H., et al. 2001. Biochem. J. 355, 481.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-July-2008 RFH
SynonymsGW647, 2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid, PPAR Agonist IV, PPARα Agonist II, PPARβ/δ Agonist I, PPARγ Agonist III
DescriptionA cell-permeable, urea-substituted, thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 6 nM for human PPARα, 1.1 µM for human PPARγ, and 6.2 µM human PPARδ; 1 nM for murine PPARα, 1.3 µM for murine PPARγ, and 2.9 µM murine PPARδ). Also shown to lower lipid levels in rats.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number265129-71-3
Chemical formulaC₂₉H₄₆N₂O₃S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (12 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesMuoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089.
Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225.
Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306.
Poirier, H., et al. 2001. Biochem. J. 355, 481.