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361554 GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Neurogenesis Inducer, TWS119

Primary Target: GSK-3β
361554
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
601514-19-6C₁₈H₁₄N₄O₂

Products

RéférenceConditionnement Qté
361554-1MG Ampoule plast. 1 mg
361554-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
Catalogue Number361554
Brand Family Calbiochem®
SynonymsNeurogenesis Inducer, TWS119
References
ReferencesDing, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.
Product Information
CAS number601514-19-6
ATP CompetitiveN
FormBeige solid
Hill FormulaC₁₈H₁₄N₄O₂
Chemical formulaC₁₈H₁₄N₄O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGSK-3β
Primary Target IC<sub>50</sub>30 nM; Kd = 126 nM against GSK-3β
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
361554-1MG 04055977214123
361554-5MG 04055977214130

Documentation

GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem Certificats d'analyse

TitreNuméro de lot
361554

Références bibliographiques

Aperçu de la référence bibliographique
Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsNeurogenesis Inducer, TWS119
DescriptionA cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number601514-19-6
Chemical formulaC₁₈H₁₄N₄O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml) or Methanol (2 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesDing, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.