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344930 Furin Inhibitor I - Calbiochem

344930
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Aperçu

Tableau de caractéristiques principal

Empirical Formula
C₃₄H₆₆ClN₁₁O₅

Products

RéférenceConditionnement Qté
344930-1MG Ampoule plast. 1 mg
Description
OverviewA peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
Catalogue Number344930
Brand Family Calbiochem®
SynonymsDecanoyl-RVKR-CMK
References
ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
Garten, W., et al. 1994. Biochimie 76, 217.
Hallenberger, S., et al. 1992. Nature 360, 358.
Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
Product Information
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₃₄H₆₆ClN₁₁O₅
Chemical formulaC₃₄H₆₆ClN₁₁O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targetviral glycoproteins
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Global Trade Item Number
Référence GTIN
344930-1MG 04055977194371