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344273 Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, CAS 115116-37-5, is a chemically-modified forskolin for greater stability and water solubility.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: L-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl

Primary Target: Adenylate cyclase
344273
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
115116-37-5C₂₉H₄₈N₂O₇ · 2HCl

Products

RéférenceConditionnement Qté
344273-10MG Ampoule plast. 10 mg
344273-5MG Ampoule plast. 5 mg
Description
OverviewChemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC50 = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells.
Catalogue Number344273
Brand Family Calbiochem®
SynonymsL-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl
References
ReferencesYang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.
Product Information
CAS number115116-37-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₄₈N₂O₇ · 2HCl
Chemical formulaC₂₉H₄₈N₂O₇ · 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationForskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, CAS 115116-37-5, is a chemically-modified forskolin for greater stability and water solubility.
Biological Information
Primary TargetAdenylate cyclase
Primary Target IC<sub>50</sub>EC50 = 13 µM in activating adenylate cyclase
Purity≥92% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 21

Harmful in contact with skin.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
344273-10MG 04055977215380
344273-5MG 04055977214642

Documentation

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem Certificats d'analyse

TitreNuméro de lot
344273

Références bibliographiques

Aperçu de la référence bibliographique
Yang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.

Brochure

Titre
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
SynonymsL-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl
DescriptionA chemically modified forskolin with greater stability and water solubility. Activates adenylate cyclase (EC50 = 13 µM).
FormWhite solid
CAS number115116-37-5
Chemical formulaC₂₉H₄₈N₂O₇ · 2HCl
Structure formulaStructure formula
Purity≥92% by HPLC
SolubilityMethanol or H₂O (12 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Toxicity Harmful
ReferencesYang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.