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509374 Fn14 Antagonist, L524-0366 - CAS 951612-19-4 - Calbiochem

Specifically binds to the Fn14 surface (Kd = 7.12 mM) and suppresses TWEAK-induced glioma cell migration.

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Synonymes: Fibroblast Growth Factor-inducible 14 Antagonist; L5240366, THD Receptor Antagonist; TNF-like Weak Inducer of Apoptosis Receptor Antagonist, TWEAK Receptor Antagonist; TWEAK-Fn14 Interaction Inhibitor

Primary Target: fibroblast growth factor-inducible 14 (Fn14)
509374
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Tableau de caractéristiques principal

CAS #Empirical Formula
951612-19-4C₁₃H₁₃ClN₄OS

Products

RéférenceConditionnement Qté
5093740001 Flacon en verre 10 mg
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Description
OverviewA triazolyl-thiomorpholinyl-methanone compound that competes against TWEAK C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 µM). Shown to completely inhibit 100 ng/mL sTWEAK-stimulated migration of T98G glioma cells at 10 µM concentration and is more potent against sTWEAK- than TNFα-induced NF-κB activation (IC50 = 7.8 vs. 31.03 µM, respectively, in reporter assays) without any apparent cytotoxicity up to 50 µM and 72 h in T98G cultures.
Catalogue Number509374
Brand Family Calbiochem®
SynonymsFibroblast Growth Factor-inducible 14 Antagonist; L5240366, THD Receptor Antagonist; TNF-like Weak Inducer of Apoptosis Receptor Antagonist, TWEAK Receptor Antagonist; TWEAK-Fn14 Interaction Inhibitor
References
ReferencesDhruv, H., et al. 2013. J. Biol. Chem. 288, 32261.
Product Information
CAS number951612-19-4
FormWhite powder
Hill FormulaC₁₃H₁₃ClN₄OS
Chemical formulaC₁₃H₁₃ClN₄OS
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Target fibroblast growth factor-inducible 14 (Fn14)
Primary Target K<sub>i</sub>7.12 µ
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
5093740001 04055977241839