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504843 Fbxo3 Inhibitor, BC-1215 - CAS 1507370-20-8 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N¹,N²-bis(4-(Pyridin-2-yl)benzyl)ethane-1,2-diamine, F Box Only Protein 3 Inhibitor, F Box Protein 3 Inhibitor, BC1215, F Box and Leucine-rich Repeat Protein 2 Activator, Fbxl2 Activator

Primary Target: Fbox3
504843
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1507370-20-8C₂₆H₂₆N₄

Products

RéférenceConditionnement Qté
5048430001 Flacon en verre 10 mg
Description
OverviewA cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination. Effectively reduces cellular TRAFs (5 to 127 µM) and prevents TRAF-mediated cytokines production from LPS-stimulated human PBMC (25 µM). Shown to greatly prevent Cecal Ligation & Puncture-induced plasma cytokine elevation and substantially reduce the severity of lung inflammation post intratracheal P. aeruginosa infection in mice (100 µg/mouse; i.p.) in vivo.
Catalogue Number504843
Brand Family Calbiochem®
SynonymsN¹,N²-bis(4-(Pyridin-2-yl)benzyl)ethane-1,2-diamine, F Box Only Protein 3 Inhibitor, F Box Protein 3 Inhibitor, BC1215, F Box and Leucine-rich Repeat Protein 2 Activator, Fbxl2 Activator
References
ReferencesChen, B.B., et al. 2013. Nat. Immunol. 14, 470.
Product Information
CAS number1507370-20-8
FormBeige solid
Hill FormulaC₂₆H₂₆N₄
Chemical formulaC₂₆H₂₆N₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFbox3
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5048430001 04055977243604

Documentation

Fbxo3 Inhibitor, BC-1215 - CAS 1507370-20-8 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Chen, B.B., et al. 2013. Nat. Immunol. 14, 470.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-September-2013 JSW
SynonymsN¹,N²-bis(4-(Pyridin-2-yl)benzyl)ethane-1,2-diamine, F Box Only Protein 3 Inhibitor, F Box Protein 3 Inhibitor, BC1215, F Box and Leucine-rich Repeat Protein 2 Activator, Fbxl2 Activator
DescriptionA cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction by targeting Fbxo3 C-terminal ApaG domain and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in upregulation of cellular Fbxl2 and thereby SCF-Fbxl2-catalyzed ubiquitination of TRAFs (TNF Receptor-Associated Factors). Effectively reduces cellular TRAFs in human macrophage U937, PBMC, and murine murine MLE cultures (16 to 18 h with 5 to 127 µM BC-1215), resulting in downregulation of TRAF-mediated cytokines production from LPS-stimulated human PBMC (2 µg/mL LPS; 25 µM BC-1215;16 h). Intraperitoneal injection in mice in vivo (100 µg/mouse) is shown to greatly prevent circulating proinflammatory cytokines increase post CLP (Cecal Ligation & Puncture) and substantially reduce the severity of cell infiltration in lung after intratracheal P. aeruginosa PA103 infection.
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1507370-20-8
Chemical formulaC₂₆H₂₆N₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesChen, B.B., et al. 2013. Nat. Immunol. 14, 470.