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341205 Etoposide - CAS 33419-42-0 - Calbiochem

Etoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.

Etoposide - CAS 33419-42-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: VP-16

Primary Target: topoisomerase 2
341205
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
33419-42-0C₂₉H₃₂O₁₃

Products

RéférenceConditionnement Qté
341205-25MG Ampoule plast. 25 mg
Description
OverviewA cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
Catalogue Number341205
Brand Family Calbiochem®
SynonymsVP-16
References
ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
Product Information
CAS number33419-42-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₃₂O₁₃
Chemical formulaC₂₉H₃₂O₁₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationEtoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.
Biological Information
Primary Targettopoisomerase 2
Primary Target IC<sub>50</sub>59.2 µM inhibiting topoisomerase II
Purity>95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSKC0190000
Safety Information
R PhraseR: 22-45

Harmful if swallowed.
May cause cancer.
S PhraseS: 26-36/37/39-45-53

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
341205-25MG 04055977215434

Documentation

Etoposide - CAS 33419-42-0 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Etoposide - CAS 33419-42-0 - Calbiochem Certificats d'analyse

TitreNuméro de lot
341205

Références bibliographiques

Aperçu de la référence bibliographique
De Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-October-2023 JSW
SynonymsVP-16
DescriptionA cell-permeable, topoisomerase II inhibitor (IC50 = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
FormWhite solid
CAS number33419-42-0
RTECSKC0190000
Chemical formulaC₂₉H₃₂O₁₃
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 3886
ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.