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324694 Emodin - CAS 518-82-1 - Calbiochem

A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC₅₀ = 18.5 µM).

Emodin - CAS 518-82-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 6-Methyl-1,3,8-trihydroxyanthraquinone

Primary Target: p56lck tyrosine kinase
324694
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
518-82-1C₁₅H₁₀O₅

Products

RéférenceConditionnement Qté
324694-50MG Flacon en verre 50 mg
Description
OverviewA cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 µM). Also suppresses HER2/neu tyrosine kinase activity in HER2/neu overexpressing breast cancer cells.
Catalogue Number324694
Brand Family Calbiochem®
Synonyms6-Methyl-1,3,8-trihydroxyanthraquinone
References
ReferencesPickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.
Product Information
CAS number518-82-1
ATP CompetitiveN
FormOrange solid
Hill FormulaC₁₅H₁₀O₅
Chemical formulaC₁₅H₁₀O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetp56lck tyrosine kinase
Primary Target IC<sub>50</sub>18.5 µM against p56lck tyrosine kinase
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSCB7920600
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
324694-50MG 04055977215892

Documentation

Emodin - CAS 518-82-1 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Emodin - CAS 518-82-1 - Calbiochem Certificats d'analyse

TitreNuméro de lot
324694

Références bibliographiques

Aperçu de la référence bibliographique
Pickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
Synonyms6-Methyl-1,3,8-trihydroxyanthraquinone
DescriptionA cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 14.8 µM) without affecting normal human bronchial epithelial cells, even at a concentration of 370 mM. Reported to act as an inhibitor of Tau aggregation and aid in the disassembly of PHF in vitro and in vivo.
FormOrange solid
CAS number518-82-1
RTECSCB7920600
Chemical formulaC₁₅H₁₀O₅
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (1 mg/ml), Ethanol or Aqueous alkali
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.
Toxicity Standard Handling
Merck USA index14, 3561
ReferencesPickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.