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341207 ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.

ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Edelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine

Primary Target: PI-PLC
341207
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
70641-51-9C₂₇H₅₈NO₆P

Products

RéférenceConditionnement Qté
341207-50MG Ampoule plast. 50 mg
341207-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
Catalogue Number341207
Brand Family Calbiochem®
SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
References
ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
Helfman, D., et al. 1993. Cancer Res. 53, 2955.
Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
Powis, G., et al. 1992. Cancer Res. 52, 2835.
Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
Product Information
CAS number70641-51-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₇H₅₈NO₆P
Chemical formulaC₂₇H₅₈NO₆P
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPI-PLC
Primary Target IC<sub>50</sub>9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYK0718000
Safety Information
R PhraseR: 40

Limited evidence of a carcinogenic effect.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
341207-50MG 04053252041402
341207-5MG 04055977215441

Documentation

ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem Certificats d'analyse

TitreNuméro de lot
341207

Références bibliographiques

Aperçu de la référence bibliographique
Harguindey, J., et al. 2000. Apoptosis 5, 87.
Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
Helfman, D., et al. 1993. Cancer Res. 53, 2955.
Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
Powis, G., et al. 1992. Cancer Res. 52, 2835.
Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.

Posters

Titre
Human Kinome & InhibitorSelect™ Libraries
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-May-2011 JSW
SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
DescriptionA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Inhibits protein kinase C from various leukemic cells. Also promotes rapid and selective apoptosis in human leukemic cells. Has strong antitumor and anticancer properties.
FormWhite solid
CAS number70641-51-9
RTECSYK0718000
Chemical formulaC₂₇H₅₈NO₆P
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO (5 mg/ml), CHCl₃ (50 mg/ml), Ethanol (5 mg/ml), or H₂O. Material may form micelles in aqueous stock solutions, which may affect experimental results.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
Toxicity Carcinogenic / Teratogenic
ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
Helfman, D., et al. 1993. Cancer Res. 53, 2955.
Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
Powis, G., et al. 1992. Cancer Res. 52, 2835.
Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.