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328000 ERK Activation Inhibitor Peptide I, Cell-Permeable - Calbiochem

The ERK Activation Inhibitor Peptide I, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications

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Synonymes: Ste-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV

Primary Target: MEK
328000
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Aperçu

Tableau de caractéristiques principal

Empirical Formula
C₈₆H₁₅₃N₁₉O₁₇S

Products

RéférenceConditionnement Qté
328000-1MG Ampoule plast. 1 mg
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Description
OverviewA cell-permeable and reversible stearated 13-amino acid peptide corresponding to the N-terminus of MEK1 (MAPKK) that acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of Elk1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 2.5 µM). Potently blocks ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells (IC50 = 13 µM). Does not affect the activation of JNKs or p38.
Catalogue Number328000
Brand Family Calbiochem®
SynonymsSte-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV
References
ReferencesKelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₈₆H₁₅₃N₁₉O₁₇S
Chemical formulaC₈₆H₁₅₃N₁₉O₁₇S
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetMEK
Primary Target IC<sub>50</sub>2.5 µM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceSte-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂ (Ste = stearated)
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
328000-1MG 04055977196337