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324630 EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem

The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor and adenosine deaminase.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: erythro-9-(2-Hydroxy-3-nonyl)adenine, HCl

Primary Target: PDE 2
324630
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
51350-19-7C₁₄H₂₃N₅O · HCl

Products

RéférenceConditionnement Qté
324630-10MG Ampoule plast. 10 mg
Description
OverviewThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
Catalogue Number324630
Brand Family Calbiochem®
Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
References
ReferencesBurton, P., et al. 2010. Biochem. J. in press.
Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
Product Information
CAS number51350-19-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₄H₂₃N₅O · HCl
Chemical formulaC₁₄H₂₃N₅O · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDE 2
Primary Target IC<sub>50</sub>0.8 and 2 µM against human and procine PDE II, respectively
Primary Target K<sub>i</sub>4 nM against adenosine deaminase
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
324630-10MG 04055977196733

Documentation

EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem Certificats d'analyse

TitreNuméro de lot
324630

Références bibliographiques

Aperçu de la référence bibliographique
Burton, P., et al. 2010. Biochem. J. in press.
Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-February-2012 RFH
Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
DescriptionThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
FormWhite solid
CAS number51350-19-7
Chemical formulaC₁₄H₂₃N₅O · HCl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityH₂O (25 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBurton, P., et al. 2010. Biochem. J. in press.
Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.