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300260 Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem

A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: DPI

Primary Target: eNOS
300260
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
4673-26-1C₁₂H₈ICl

Products

RéférenceConditionnement Qté
300260-10MG Ampoule plast. 10 mg
Description
OverviewA cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Also inhibits iNOS in macrophages (IC50 = 50 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADPH-ubiquinone oxido-reductase.
Catalogue Number300260
Brand Family Calbiochem®
SynonymsDPI
References
ReferencesWang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.
Product Information
CAS number4673-26-1
ATP CompetitiveN
FormOff-white crystalline solid
Hill FormulaC₁₂H₈ICl
Chemical formulaC₁₂H₈ICl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargeteNOS
Primary Target IC<sub>50</sub>180 nM against endothelial nitric oxide synthase (eNOS)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 42/43-63

May cause sensitization by inhalation and skin contact.
Possible risk of harm to the unborn child.
S PhraseS: 22-26-36

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
300260-10MG 04055977197976

Documentation

Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem Certificats d'analyse

TitreNuméro de lot
300260

Références bibliographiques

Aperçu de la référence bibliographique
Wang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.

Brochure

Titre
Pathways and Biomarkers of Oxidative Stress
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-June-2008 RFH
SynonymsDPI
DescriptionA cell-permeable, irreversible endothelial nitric oxide synthase inhibitor. Inhibits iNOS in macrophages (IC50 = 5 nM). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADH-ubiquinone oxidoreductase. Inhibits other NADH utilizing flavoproteins, such as NADPH oxidase in human neutrophils and macrophages. Causes pressor and tachycardiac effects via indirect activation of the sympathetic nervous system.
FormOff-white crystalline solid
CAS number4673-26-1
Chemical formulaC₁₂H₈ICl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml). Slight warming is required for complete solubility.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesWang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.