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508321 Dihydroorotate Dehydrogenase Inhibitor, Brequinar - CAS 96201-88-6 - Calbiochem

An immunosuppressive and anti-neoplastic agent that inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC₅₀ = 12 nM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785

Primary Target: DHODH
508321
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
96201-88-6C₂₃H₁₄F₂NNaO₂

Products

RéférenceConditionnement Qté
5083210001 Flacon en verre 10 mg
Description
OverviewA quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM).
Catalogue Number508321
Brand Family Calbiochem®
Synonyms6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785
References
ReferencesHe, T. et al. 2013. Oncogene 32, in press.
Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1610.
Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents. 38, 435.
Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett. 14, 1549.
Allison, A., et al. 1993. Transplantation Proc. 25, 67.
Cramer, D. et al. 1992. Transplantation. 53, 303.
Product Information
CAS number96201-88-6
FormOff-white solid
Hill FormulaC₂₃H₁₄F₂NNaO₂
Chemical formulaC₂₃H₁₄F₂NNaO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDHODH
Primary Target IC<sub>50</sub>12 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5083210001 04055977261899

Documentation

Dihydroorotate Dehydrogenase Inhibitor, Brequinar - CAS 96201-88-6 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
He, T. et al. 2013. Oncogene 32, in press.
Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1610.
Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents. 38, 435.
Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett. 14, 1549.
Allison, A., et al. 1993. Transplantation Proc. 25, 67.
Cramer, D. et al. 1992. Transplantation. 53, 303.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-January-2014 JSW
Synonyms6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785
DescriptionA quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number96201-88-6
Chemical formulaC₂₃H₁₄F₂NNaO₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHe, T. et al. 2013. Oncogene 32, in press.
Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1610.
Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents. 38, 435.
Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett. 14, 1549.
Allison, A., et al. 1993. Transplantation Proc. 25, 67.
Cramer, D. et al. 1992. Transplantation. 53, 303.