Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

266785 Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem

The Diacylglycerol Kinase Inhibitor I, also referenced under CAS 93076-89-2, controls the biological activity of Diacylglycerol Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: R59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one

Primary Target: Diacylglycerol Kinase
266785
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
93076-89-2C₂₇H₂₆FN₃OS

Products

RéférenceConditionnement Qté
266785-5MG Ampoule plast. 5 mg
Description
OverviewPotentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin S2 antagonist.
Catalogue Number266785
Brand Family Calbiochem®
SynonymsR59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one
References
ReferencesGoin, M., et al. 1993. FEBS Lett. 316, 68.
Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418.
de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.
Product Information
CAS number93076-89-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₇H₂₆FN₃OS
Chemical formulaC₂₇H₂₆FN₃OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDiacylglycerol Kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
266785-5MG 04055977197761

Documentation

Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem Certificats d'analyse

TitreNuméro de lot
266785

Références bibliographiques

Aperçu de la référence bibliographique
Goin, M., et al. 1993. FEBS Lett. 316, 68.
Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418.
de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.

Citations

Titre
  • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
    		•
    Fiche technique

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision16-June-2008 RFH
    SynonymsR59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one
    DescriptionPotentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Potentiates this effect in studies of signal-transducing inositol lipid metabolism. Inhibits human platelet DAG kinase in intact cells (IC50 = 3.6 µM) and in isolated membranes (IC50 = 6.7 µM). In porcine thymus cytosol it inhibits the 80 kDa DAG kinase (IC50 = 10 µM) but has no effect on the 150 kDa DAG kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin-S2 antagonist.
    FormWhite solid
    CAS number93076-89-2
    Chemical formulaC₂₇H₂₆FN₃OS
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (4 mg/ml) or Ethanol (12 mg/ml)
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
    Toxicity Irritant
    ReferencesGoin, M., et al. 1993. FEBS Lett. 316, 68.
    Ohtsuka, T., et al. 1990. J. Biol. Chem. 265, 15418.
    de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem. 260, 15762.
    Citation
  • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
    		•