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219477 Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem

The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor

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Synonymes: 1,4-Dimethoxyacridine-9(10H)-thione

Primary Target: CDK4/D1
219477
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Tableau de caractéristiques principal

CAS #Empirical Formula
141992-47-4C₁₅H₁₃NO₂S

Products

RéférenceConditionnement Qté
219477-5MG Flacon en verre 5 mg
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Description
OverviewA thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 > 100 µM).
Catalogue Number219477
Brand Family Calbiochem®
Synonyms1,4-Dimethoxyacridine-9(10H)-thione
References
ReferencesKubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.
Product Information
CAS number141992-47-4
ATP CompetitiveN
FormBrown solid
Hill FormulaC₁₅H₁₃NO₂S
Chemical formulaC₁₅H₁₃NO₂S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCDK4/D1
Primary Target IC<sub>50</sub>200 nM against CDK4/D1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
219477-5MG 04055977218541