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219555 Cathepsin K Substrate II, Fluorogenic - Calbiochem

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Abz-HPG~GPQ-EDN₂ph

219555
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Aperçu

Replacement Information

Products

RéférenceConditionnement Qté
219555-1MG Ampoule plast. 1 mg
Description
OverviewAn internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM-1 S-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates.
Catalogue Number219555
Brand Family Calbiochem®
SynonymsAbz-HPG~GPQ-EDN₂ph
References
ReferencesLecaille, F., et al. 2003. Biochem. J. 375, 307.
Product Information
FormBright yellow solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₄₀H₅₀N₁₄O₁₂
Chemical formulaC₄₀H₅₀N₁₄O₁₂
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Emission max.
Excitation max.
Peptide SequenceAbz-His-Pro-Gly~Gly-Pro-Gln-EDDnp
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
219555-1MG 04055977218114

Documentation

Cathepsin K Substrate II, Fluorogenic - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Cathepsin K Substrate II, Fluorogenic - Calbiochem Certificats d'analyse

TitreNuméro de lot
219555

Références bibliographiques

Aperçu de la référence bibliographique
Lecaille, F., et al. 2003. Biochem. J. 375, 307.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-August-2009 RFH
SynonymsAbz-HPG~GPQ-EDN₂ph
DescriptionAn internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM-1 S-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates. Emission Max: 420 NM, Excitation Max: 320 nM.
FormBright yellow solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₀H₅₀N₁₄O₁₂
Peptide SequenceAbz-His-Pro-Gly~Gly-Pro-Gln-EDDnp
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLecaille, F., et al. 2003. Biochem. J. 375, 307.