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264158 Caspase Modulator II, 1541B - Calbiochem

Caspase Modulator II, 1541B primarily used in Inhibition.

Caspase Modulator II, 1541B - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Procaspase-3 Activator III, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI

264158
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₃H₁₅N₃O₄

Products

RéférenceConditionnement Qté
264158-10MG 10 mg
Description
OverviewA cell-permeable, of 8-Hydroxy analog 1541 (Cat. No. 529662) that is shown to selectively activate procaspase-3 (EC50 = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective in cell death induction as simultaneous activations of caspase-3/-6 among cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.
Catalogue Number264158
Brand Family Calbiochem®
SynonymsProcaspase-3 Activator III, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI
References
ReferencesWolan, D.W., et al. 2009. Science 326, 853.
Product Information
FormPale yellow solid
Hill FormulaC₂₃H₁₅N₃O₄
Chemical formulaC₂₃H₁₅N₃O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
264158-10MG 04055977198492

Documentation

Caspase Modulator II, 1541B - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Caspase Modulator II, 1541B - Calbiochem Certificats d'analyse

TitreNuméro de lot
264158

Références bibliographiques

Aperçu de la référence bibliographique
Wolan, D.W., et al. 2009. Science 326, 853.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-June-2011 RFH
SynonymsProcaspase-3 Activator III, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI
DescriptionA cell-permeable, of 8-Hydroxy 1541 (Cat. No. 529662) analog that is shown to selectively activate procaspase-3 (EC50 = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective as simultaneous activations of caspase-3/-6 in cell death induction of the cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₁₅N₃O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (1.8 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWolan, D.W., et al. 2009. Science 326, 853.