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236005 COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem

The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is primarily used for Cell Signaling applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride

Primary Target: COX-1, COX-2
236005
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
130717-51-0C₂₃H₂₅N₃O₃S • HCl

Products

RéférenceConditionnement Qté
236005-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable trisubstituted thiazole compound that acts as a potent and selective inhibitor of COX-1 (IC50 = 28 nM and 65 µM for human recombinant COX-1 and COX-2, respectively). Displays ~2,300 fold greater selectivity towards inhibition of COX-1 over COX-2. Reported to be orally active and display analgesic, anti-platelet and anti-inflammatory properties.
Catalogue Number236005
Brand Family Calbiochem®
SynonymsFR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride
References
ReferencesOchi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782.
Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49.
Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189.
Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.
Product Information
CAS number130717-51-0
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₂₃H₂₅N₃O₃S • HCl
Chemical formulaC₂₃H₂₅N₃O₃S • HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1, COX-2
Primary Target IC<sub>50</sub>28 nM and 65 µM for human recombinant COX-1 and COX-2
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
236005-5MG 04055977217100

Documentation

COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem Certificats d'analyse

TitreNuméro de lot
236005

Références bibliographiques

Aperçu de la référence bibliographique
Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782.
Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49.
Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189.
Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-June-2008 RFH
SynonymsFR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride
DescriptionA potent, cell-permeable, and selective inhibitor of COX-1 (IC50 = 28 nM; human recombinant COX-1). Does not significantly inhibit COX-2 (IC50 = 65 µM, human recombinant COX-2). Reported to be orally active and displays analgesic properties in chemical nociceptive animal models. Also reported to exhibit anti-inflammatory effects and suppress prostaglandin E2 and thromboxane 2 levels in collagen-induced arthritis in rats. Shown to be 100 times more potent than aspirin in inhibiting arachidonic acid- and collagen-induced human and guinea pig platelet aggregation.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number130717-51-0
Chemical formulaC₂₃H₂₅N₃O₃S • HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml), H₂O (4 mg/ml), or 1 N HCl (2 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesOchi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782.
Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49.
Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189.
Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.