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538763 CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Compound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor

Primary Target: CD38
538763
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1700637-55-3C₂₂H₂₇N₃O₃S

Products

RéférenceConditionnement Qté
5387630001 Flacon en verre 10 mg
Description
OverviewA cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cmax = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cmax = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
Catalogue Number538763
Brand Family Calbiochem®
SynonymsCompound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
References
ReferencesHaffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.
Product Information
CAS number1700637-55-3
FormWhite to light brown to brown solid
Hill FormulaC₂₂H₂₇N₃O₃S
Chemical formulaC₂₂H₂₇N₃O₃S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetCD38
Primary Target IC<sub>50</sub>7.3 & 1.9 nM for human & mouse CD38, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5387630001 04054839119507

Documentation

CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem Certificats d'analyse

TitreNuméro de lot
538763

Références bibliographiques

Aperçu de la référence bibliographique
Haffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-July-2019 JSW
SynonymsCompound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
DescriptionA cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cmax = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cmax = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
FormWhite to light brown to brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1700637-55-3
Chemical formulaC₂₂H₂₇N₃O₃S
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHaffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.