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203811 Bryostatin 1 - CAS 83314-01-6 - Calbiochem

A macrocyclic lactone with antitumor properties.

Bryostatin 1 - CAS 83314-01-6 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Bryo 1, PKC Activator VII, PKC Activator VI

Primary Target: Protein kinase C
203811
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
83314-01-6C₄₇H₆₈O₁₇

Products

RéférenceConditionnement Qté
203811-10UG Ampoule plast. 10 μg
Description
OverviewA macrocyclic lactone with antitumor properties. Potently activates protein kinase C and exhibits a high binding affinity (Ki = 1.35 nM). Effectively translocates and down-regulates PKC isozymes α, δ, and ε. Induces a biphasic activation of PKD through a PKC-dependent pathway in intact cells. Also shown to activate Ras in Jurkat T cells and in rat2 cells.
Catalogue Number203811
Brand Family Calbiochem®
SynonymsBryo 1, PKC Activator VII, PKC Activator VI
References
ReferencesClamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673.
Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137.
Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233.
Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624.
Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245.
Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840.
Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.
Product Information
CAS number83314-01-6
ATP CompetitiveN
FormWhite to colorless solid or film
Hill FormulaC₄₇H₆₈O₁₇
Chemical formulaC₄₇H₆₈O₁₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetProtein kinase C
Primary Target K<sub>i</sub>1.35 nM for protein kinase C
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEH9455000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
203811-10UG 04055977204025

Documentation

Bryostatin 1 - CAS 83314-01-6 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Bryostatin 1 - CAS 83314-01-6 - Calbiochem Certificats d'analyse

TitreNuméro de lot
203811

Références bibliographiques

Aperçu de la référence bibliographique
Clamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673.
Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137.
Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233.
Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624.
Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245.
Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840.
Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
SynonymsBryo 1, PKC Activator VII, PKC Activator VI
DescriptionA macrocyclic lactone that exhibits anti-tumor properties. Potently activates protein kinase C and exhibits high binding affinity (Ki = 1.35 nM). Effectively translocates protein kinase C (PKC) isozymes α, β, and ε and induces a biphasic, concentration-dependent, down-regulation of PKC δ. Reported to compete with phorbol esters in binding to PKC. Stimulates protein kinase D (PKD) activity in a biphasic, PKC-dependent manner in intact cells. Also activates Ras in Jurkat T cells and in rat2 cells.
FormWhite to colorless solid or film
CAS number83314-01-6
RTECSEH9455000
Chemical formulaC₄₇H₆₈O₁₇
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (25 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 1457
ReferencesClamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673.
Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137.
Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233.
Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624.
Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245.
Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840.
Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.