203646 Sigma-AldrichBMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem
The BMP Inhibitor II, DMH1, also referenced under CAS 1206711-16-1, controls the biological activity of BMP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation
More>> The BMP Inhibitor II, DMH1, also referenced under CAS 1206711-16-1, controls the biological activity of BMP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
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Aperçu
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 1206711-16-1 | C₂₄H₂₀N₄O |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 203646-5MG | Flacon en verre | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable, potent, and highly selective BMPR inhibitior (IC50 against human ALK2/BMPR-I = 107.9 nM), exhibiting no activity toward ALK5, ALK6, AMPK, FLK1/KDR/VEGRF2, or PDGFRβ. Comparing to its non-BMPR-selective structural analog dorsomorphin (Cat. Nos. 171260 & 171261), DMH1 is 12.5-times more potent in preventing BMP pathway-dependent dorsoventral development (EC100 = 0.2 µM) in zebrafish embryo in vivo, while being non-toxic to the fish embryo and exhibiting no effect against VEGF signaling-dependent intersomitic vessel formation even at concentrations as high as 50 µM. |
| Catalogue Number | 203646 |
| Brand Family | Calbiochem® |
| Synonyms | ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline |
| References | |
|---|---|
| References | Hao, J., et al. 2010. ACS Chem.Biol. 5, 245. |
| Product Information | |
|---|---|
| CAS number | 1206711-16-1 |
| Form | Orange solid |
| Hill Formula | C₂₄H₂₀N₄O |
| Chemical formula | C₂₄H₂₀N₄O |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 203646-5MG | 04055977204384 |