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178385 Apocynin - CAS 498-02-2 - Calbiochem

A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.

Apocynin - CAS 498-02-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V

Primary Target: NADPH oxidase
178385
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
498-02-2C₉H₁₀O₃

Products

RéférenceConditionnement Qté
178385-1GM Ampoule plast. 1 gm
Description
OverviewA cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
Catalogue Number178385
Brand Family Calbiochem®
Synonyms4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
References
ReferencesAbid, M.R., et al. 2000. FEBS Lett. 486, 252.
Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.
Product Information
CAS number498-02-2
ATP CompetitiveN
FormWhite to off-white powder
Hill FormulaC₉H₁₀O₃
Chemical formulaC₉H₁₀O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNADPH oxidase
Purity≥98% by GC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSAM8800000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
178385-1GM 04055977222463

Documentation

Apocynin - CAS 498-02-2 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Apocynin - CAS 498-02-2 - Calbiochem Certificats d'analyse

TitreNuméro de lot
178385

Références bibliographiques

Aperçu de la référence bibliographique
Abid, M.R., et al. 2000. FEBS Lett. 486, 252.
Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.

Brochure

Titre
Pathways and Biomarkers of Oxidative Stress
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-February-2018 JSW
Synonyms4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
DescriptionA cell-permeable, anti-inflammatory phenol that acts as a potent and selective inhibitor of NADPH oxidase. Also blocks peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through the activation of AP-1. Shown to prevent phagocytosis of myelin by macrophages (10 mM).
FormWhite to off-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number498-02-2
RTECSAM8800000
Chemical formulaC₉H₁₀O₃
Structure formulaStructure formula
Purity≥98% by GC
SolubilityDMSO (10 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
Merck USA index14, 741
ReferencesAbid, M.R., et al. 2000. FEBS Lett. 486, 252.
Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.