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07-875 Anti-phospho-PKCδ (Ser664) Antibody

Detect phospho-PKCδ (Ser664) using this Anti-phospho-PKCδ (Ser664) Antibody validated for use in WB.

Anti-phospho-PKCδ (Ser664) Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: PRKCD, MGC49908, nPKC-delta, MAY1 UniProt Number: Q05655
07-875
100 µL  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number07-875
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-phospho-PKCδ (Ser664) Antibody
Alternate Names
  • PRKCD
  • PKC delta
  • PKCd
  • Protein Kinase C, delta
References
Product Information
FormatAffinity Purified
Presentation100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
Quality LevelMQ100
Applications
ApplicationDetect phospho-PKCδ (Ser664) using this Anti-phospho-PKCδ (Ser664) Antibody validated for use in WB.
Key Applications
  • Western Blotting
Application NotesImmunoblot Analysis: A 1:1,000 dilution of this lot detected phospho-PKCδ (Ser664) in RIPA lysate of PMA-treated K562 cells.
Biological Information
ImmunogenPeptide corresponding to amino acid region encompassing the human phospho-PKCδ (Ser664).
HostRabbit
SpecificityRecognizes phospho-PKCδ (Ser664), weaker with with mouse and rat PKCδ (Ser662) and PKCα (Ser657) and PKCβII (Ser662).
IsotypeIgG
Species Reactivity
  • Human
Species Reactivity NotePredicted to cross-react more weakly with mouse based on sequence homology, but have not been tested.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
Gene Symbol
  • PRKCD
  • MGC49908
  • nPKC-delta
  • MAY1
Modifications
  • Phosphorylation
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q05655 # This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function.
SIZE: 676 amino acids; 77477 Da
SUBUNIT: Interacts with PDK1 (By similarity). Interacts with RAD9A and CDCP1.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
DOMAIN: SwissProt: Q05655 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor. & The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.
PTM: Phosphorylated on Thr-507, within the activation loop. Autophosphorylated and/or phosphorylated. Although the Thr-507 phosphorylation occurs it is not a prerequisite for enzymatic activity (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
Molecular Weight78 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
07-875 04053252740824

Documentation

Anti-phospho-PKCδ (Ser664) Antibody FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-phospho-PKCδ (Ser664) Antibody Certificats d'analyse

TitreNuméro de lot
Anti- phospho-PKC#948; (Ser664) - 2152449 2152449
Anti- phospho-PKCd (Ser664) (Affinity purified Rabbit polyclonal IgG) - 2092613 2092613
Anti- phospho-PKCd (Ser664) (Affinity purified Rabbit polyclonal IgG) - 2205914 2205914
Anti- phospho-PKCd (Ser664) (Affinity purified Rabbit polyclonal IgG) - 2274234 2274234
Anti- phospho-PKCd (Ser664) - 2007679 2007679
Anti- phospho-PKCd (Ser664) - DAM1661016 DAM1661016
Anti- phospho-PKCδ (Ser664) (Affinity purified Rabbit polyclonal IgG) 3133571
Anti- phospho-PKCδ (Ser664) (Affinity purified Rabbit polyclonal IgG) 2919747
Anti- phospho-PKCδ (Ser664) (Affinity purified Rabbit polyclonal IgG) 3123683
Anti- phospho-PKCδ (Ser664) (Affinity purified Rabbit polyclonal IgG) 3128916
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