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07-868 Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody

This Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody is validated for use in WB for the detection of phospho-PKA Catalytic β subunit (Ser338).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: PRKACB, PKACB, MGC41879, MGC9320, DKFZp781I2452 UniProt Number: P22694
07-868
100 µL  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number07-868
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-phospho-PKA Catalytic β subunit (Ser338) Antibody
References
Product Information
FormatAffinity Purified
Presentation100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
Quality LevelMQ100
Applications
ApplicationThis Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody is validated for use in WB for the detection of phospho-PKA Catalytic β subunit (Ser338).
Key Applications
  • Western Blotting
Biological Information
ImmunogenPeptide corresponding to amino acid region encompassing the human, cow, and pig phospho-PKA Catalytic β (Ser338).
HostRabbit
SpecificityRecognizes phospho-PKA Catalytic β subunit (Ser338).
IsotypeIgG
Species Reactivity
  • Mouse
Species Reactivity NotePredicted to cross-react with human based on sequence homology (100% homologous).
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.
Gene Symbol
  • PRKACB
  • PKACB
  • MGC41879
  • MGC9320
  • DKFZp781I2452
Modifications
  • Phosphorylation
Purification MethodImmunoAffinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P22694 # Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.
COFACTOR: Magnesium.
SIZE: 351 amino acids; 40623 Da
SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
TISSUE SPECIFICITY: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoforms 3 and 4 are only epxressed in the brain.
PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
SIMILARITY: SwissProt: P22694 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Molecular Weight~40 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
07-868 04053252513978

Documentation

Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody Certificats d'analyse

TitreNuméro de lot
Anti-phospho-PKA Catalytic b subunit (Ser338) (Affinity purified Rabbit polyclonal IgG) - 2015531 2015531
Anti-phospho-PKA Catalytic b subunit (Ser338) (Affinity purified Rabbit polyclonal IgG) - 2273802 2273802
Anti-phospho-PKA Catalytic b subunit (Ser338) - DAM1487535 DAM1487535
Anti-phospho-PKA Catalytic b subunit (Ser338) - DAM1588196 DAM1588196
Anti-phospho-PKA Catalytic b subunit (Ser338) - NG1900703 NG1900703
Anti-phospho-PKA Catalytic β subunit (Ser338) (Affinity purified Rabbit polyclonal IgG) 2983454
Anti-phospho-PKA Catalytic β subunit (Ser338) - 2530513 2530513
Anti-phospho-PKA Catalytic β subunit (Ser338) - 3448832 3448832
Anti-phospho-PKA Catalytic β subunit (Ser338) - 3904625 3904625
Anti-phospho-PKA Catalytic β subunit (Ser338) - 3914215 3914215
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