Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABN1009 Anti-TRPA1 Antibody

Anti-TRPA1 Antibody is an antibody against TRPA1 for use inWestern Blotting and Immunohistochemistry.

Anti-TRPA1 Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: TRPA1, ANKTM1 UniProt Number: O75762
ABN1009
50 µg  
Purchase on Sigma-Aldrich

Offres spéciales

Aperçu

Replacement Information

Offres spéciales

100% Performance Guaranteed

Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
R, H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN1009
DescriptionAnti-TRPA1 Antibody
Alternate Names
  • Transient receptor potential cation channel subfamily A member 1
  • TRPA1
  • Ankyrin-like with transmembrane domains protein 1
  • Transformation-sensitive protein p120
Background InformationTransient receptor potential A1 (also known as Transient receptor potential ankyrin 1) is an excitatory ion channel on primary sensory nerves of the pain pathway. It is encoded by the TRPA1/ANKTM1 gene in human (Trpa1/Anktm1 in rat & mouse) and plays a critical role in pain associated with tissue injury, inflammation, and nerve lesions. TRPA1 is reported to colocalize with PAR2 and coexpress with TRPV1 (Transient receptor potential vanilloid 1) in rat dorsal root ganglion (DRG) neurons. Agonist-induced TRPA1 current is shown to be enhanced upon PAR2 cleavage/activation by proinflammatory trypsin & tryptase (PMID 17571167). TRPA1 activation, in turn, is reported to result in enhanced TRPV1 phosphorylation and activity in a calcium- and PKA-dependent manner (PMID 24275229).
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-TRPA1 Antibody is an antibody against TRPA1 for use inWestern Blotting and Immunohistochemistry.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected TRPA1 in rat cerebellum, rat hindbrain, and rat pancreas tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRPA1.
Epitopecytoplasmic domain
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Rat
  • Human
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • TRPA1
  • ANKTM1
Purification MethodAffinity
UniProt Number
Molecular Weight~130 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in rat brain membrane tissue lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected TRPA1 in 10 µg of rat brain membrane tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
ABN1009 04055977161878

Documentation

Anti-TRPA1 Antibody FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-TRPA1 Antibody Certificats d'analyse

TitreNuméro de lot
Anti-TRPA1 - 3174763 3174763
Anti-TRPA1 - 3229375 3229375
Anti-TRPA1 - 3256600 3256600
Anti-TRPA1 - 3594289 3594289
Anti-TRPA1 - 3936227 3936227
Anti-TRPA1 -Q2559154 Q2559154
Anti-TRPA1 Polyclonal Antibody 2953746
Anti-TRPA1 Polyclonal Antibody 2927498
Anti-TRPA1 Polyclonal Antibody 3043517
Anti-TRPA1 Polyclonal Antibody 2879526

Informations techniques

Titre
White Paper: Further considerations of antibody validation and usage.