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AB3516P Anti-Sodium-Calcium Exchanger 1 Antibody

AB3516P
50 µg  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
RELISA, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB3516P
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Sodium-Calcium Exchanger 1 Antibody
Alternate Names
  • NCX1
Product Information
FormatAffinity Purified
HS Code3002 15 90
PresentationAffinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA.
Quality LevelMQ100
Applications
ApplicationAnti-Sodium-Calcium Exchanger 1 Antibody is an antibody against Sodium-Calcium Exchanger 1 for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application NotesWestern blot: 1-10 μg/mL using ECL.





ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide per well.

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenA 23 amino acid peptide sequence within the cytoplasmic domain 3 rat NCX1 (Low et al. 1993; Furman et al. 1993; Lee et al. 1994; Nicoll et al. 1996; Kumoro et al. 1992; Blaustein & Lederer 1999).
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes rat Sodium Calcium Exchanger 1 (NCX1). The immunogen shows no significant sequence homology with other NCX proteins.
Species Reactivity
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryIn cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM]
Gene Symbol
  • SLC8A1
  • NCX1
  • DKFZp779F0871
  • +Ca
  • CNC
  • Na
  • MGC119581
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P32418 # Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
SIZE: 973 amino acids; 108547 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Cardiac sarcolemma.
SIMILARITY: SwissProt: P32418 ## Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. & Contains 2 Calx-beta domains.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µg
Global Trade Item Number
Référence GTIN
AB3516P 04053252740145