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MABC730 Anti-SCARB1 Antibody, clone 5B8.2

Detect SCARB1 using this Anti-SCARB1 Antibody, clone 5B8.2 validated for use in western blotting & IHC.

Anti-SCARB1 Antibody, clone 5B8.2 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: SCARB1, CD36L1, CLA1 UniProt Number: Q8WTV0
MABC730
100 µg  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC730
DescriptionAnti-SCARB1 Antibody, clone 5B8.2
Alternate Names
  • Scavenger receptor class B member 1
  • SRB1
  • CD36 and LIMPII analogous 1
  • CLA-1
  • CD36 antigen-like 1
  • Collagen type I receptor, thrombospondin receptor-like 1
  • SR-BI
  • CD36
Background InformationScavenger receptor class B member 1 (SCARB1), or CD36L1, is the membrane bound cell surface receptor for high density lipoprotein (HDL) as well as a number of related compounds such as phospholipids, cholesterol ester, and phosphatidylserine and apoptotic cells (via their expression of phosphatidylserine on their extracellular surfaces). SCARB1 is also the receptor for Hepatitis C virus glycoprotein E2 and it facilitates the attachment and entry of HCV. SCARB1 plays a critical role in cholesterol homeostasis and mediates cholesterol transfer to and from the HDL protein carriers, a process known as reverse cholesterol transport. It is highly expressed in tissues that require free cholesterol such as the liver and steroidogenic tissues (adrenals, testis, ovary). SCARB1 expression has also been associated with particular cancers including chronic myeloid leukemia (CML), breast cancer, bladder carcinoma, and prostate cancer.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect SCARB1 using this Anti-SCARB1 Antibody, clone 5B8.2 validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SCARB1 in human adrenal gland tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human SCARB1.
EpitopeExtracellular domain
Clone5B8.2
Concentration1 mg/mL
HostMouse
IsotypeIgMκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • SCARB1
  • CD36L1
  • CLA1
UniProt Number
Molecular Weight~61 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human adrenal tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SCARB1 in 10 µg of human adrenal tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
MABC730 04053252975608