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AB4350 Anti-PRDM14 Antibody

AB4350
100 µL  
Purchase on Sigma-Aldrich

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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB4350
DescriptionAnti-PRDM14 Antibody
Alternate Names
  • PR domain zinc finger protein 14
  • PR domain-containing protein 14
Background InformationPR domain proteins (PRDMs) have been associated with many types of human cancers. PRDM14 was found to be up-regulated in breast cancer cells. The expression of PRDM14 to breast cancer cells actually increased cell proliferation and decreased the effect of chemotherapeutic drugs, while down-regulation of PRDM14 did the opposite. In addition to breast cancer, PRDM14 has recently been linked to non-small cell lung cancer development. PRDM14 also seems to play a role in the preservation of the self-renewal of human embryonic stem cells and transcriptional regulation.
References
Product Information
FormatAffinity Purified
Control
  • Human lung tissue lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl and 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-PRDM14 Antibody is validated for use in WB for the detection of PRDM14.
Key Applications
  • Western Blotting
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the N-terminus of human PRDM14.
EpitopeN-terminus
HostRabbit
SpecificityThis antibody recognizes the N-terminus of PRDM14.
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummarySummary: The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM14, are often involved in transcriptional regulation (Jiang and Huang, 2000 [PubMed 10668202]).[supplied by OMIM].
Gene Symbol
  • PRDM14
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: May be involved in transcriptional regulation.

SUBCELLULAR LOCATION: Nucleus (potential).

SEQUENCE SIMILARITIES: Contains 6 C2H2-type zinc fingers. Contains 1 SET domain.
Molecular Weight~62 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: A 1:1000 dilution of this antibody detected PRDM14 in 10 µg of human lung tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
AB4350 04053252421747

Documentation

Anti-PRDM14 Antibody FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-PRDM14 Antibody Certificats d'analyse

TitreNuméro de lot
Anti-PRDM14 2477276
Anti-PRDM14 2475903
Anti-PRDM14 - 2383604 2383604
Anti-PRDM14 - 2043930 2043930
Anti-PRDM14 - 3252900 3252900
Anti-PRDM14 - 3698169 3698169
Anti-PRDM14 - NRG1903975 NRG1903975
Anti-PRDM14 -2741410 2741410
Anti-PRDM14 -2887508 2887508
Anti-PRDM14 Polyclonal Antibody 2897240

Références bibliographiques

Aperçu de la référence bibliographiqueNº PubMed
SOX17 is a critical specifier of human primordial germ cell fate.
Irie, N; Weinberger, L; Tang, WW; Kobayashi, T; Viukov, S; Manor, YS; Dietmann, S; Hanna, JH; Surani, MA
Cell  160  253-68  2015

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