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528215 Anti-PAI-1 Mouse mAb (MA-33B8)

This Anti-PAI-1 Mouse mAb (MA-33B8) is validated for use in Immunoblotting, Neutralization Studies for the detection of PAI-1.

Anti-PAI-1 Mouse mAb (MA-33B8) : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Anti-Plasminogen Activator Inihibitor-1

528215
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Species ReactivityHostAntibody Type
H, RbMMonoclonal Antibody

Products

RéférenceConditionnement Qté
528215-100UG Ampoule plast. 100 μg
Description
OverviewRecognizes the ~50 kDa PAI-1 protein.
Catalogue Number528215
Brand Family Calbiochem®
SynonymsAnti-Plasminogen Activator Inihibitor-1
References
ReferencesMontes, R., et al. 2000. Thromb. Haemost. 84, 65.
Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
Product Information
FormLiquid
FormulationIn 100 mM NaCl, 50 mM sodium phosphate buffer, pH 7.4.
PreservativeNone
Quality LevelMQ100
Applications
Application ReferencesNeutralization Studies Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
Key Applications Immunoblotting (Western Blotting)
Neutralization Studies
Application NotesImmunoblotting (10 µg/ml)
Neutralization Studies (see application references)
Application CommentsRapidly inactivates PAI-1 (Plasminogen Activator Inhibitor-1) to the latent form. Like the native latent form, PAI-1 inactivated by antibody was protected from cleavage by elastase. Also shown to reduce renal fibrin deposits in a rabbit model of endotoxemia. Variables associated with assay conditions will dictate the proper working dilution.
Biological Information
Immunogenhuman tPA-PAI-1 complex
ImmunogenHuman
CloneMA-33B8
HostMouse
Purity≥ 90% by SDS-PAGE
IsotypeIgG
Species Reactivity
  • Human
  • Rabbit
Antibody TypeMonoclonal Antibody
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
528215-100UG 04055977196511

Documentation

Anti-PAI-1 Mouse mAb (MA-33B8) FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-PAI-1 Mouse mAb (MA-33B8) Certificats d'analyse

TitreNuméro de lot
528215

Références bibliographiques

Aperçu de la référence bibliographique
Montes, R., et al. 2000. Thromb. Haemost. 84, 65.
Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-March-2009 JSW
SynonymsAnti-Plasminogen Activator Inihibitor-1
ApplicationImmunoblotting (10 µg/ml)
Neutralization Studies (see application references)
DescriptionPurified mouse monoclonal antibody. Recognizes the ~50 kDa PAI-1 protein.
HostMouse
Immunogen speciesHuman
Immunogenhuman tPA-PAI-1 complex
CloneMA-33B8
IsotypeIgG
Specieshuman, rabbit
FormLiquid
FormulationIn 100 mM NaCl, 50 mM sodium phosphate buffer, pH 7.4.
Concentration Label Please refer to vial label for lot-specific concentration
Purity≥ 90% by SDS-PAGE
PreservativeNone
CommentsRapidly inactivates PAI-1 (Plasminogen Activator Inhibitor-1) to the latent form. Like the native latent form, PAI-1 inactivated by antibody was protected from cleavage by elastase. Also shown to reduce renal fibrin deposits in a rabbit model of endotoxemia. Variables associated with assay conditions will dictate the proper working dilution.
Storage Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesMontes, R., et al. 2000. Thromb. Haemost. 84, 65.
Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
Application referencesNeutralization Studies Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.