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ABT1382-25UL Anti-Neurocan

This rabbit polyclonal Anti-Neurocan, Cat. No. ABT1382, is a rabbit polyclonal antibody that detects Neurocan core protein and has been tested for use in Immunofluorescence.

ABT1382-25UL
25 µL  
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Replacement Information
Description
Catalogue NumberABT1382-25UL
DescriptionAnti-Neurocan
Alternate Names
  • Neurocan core protein
  • 245 kDa early postnatal core glycoprotein
  • Chondroitin sulfate proteoglycan 3
Background InformationNeurocan core protein (UniProt: P55067; also known as 245 kDa early postnatal core glycoprotein, Chondroitin sulfate proteoglycan 3) is encoded by the Ncan (also known as Cspg3) gene in rat. Neurocan is a secreted protein of the aggrecan/versican proteoglycan family that is found in early postnatal and adult brain. During early postnatal development neurocan accounts for at least 20% of the protein of the soluble brain proteoglycans. Neurocan mostly contains chondroitin sulfate, but also has N-linked and O-linked oligosaccharides. It is shown to be involved in the modulation of cell adhesion and migration and regulates neurite outgrowth. Neurocan interact with several cell surface molecules, such as N-CAM, L1/Ng-CAM, etc., and modulates the cell-binding and neurite outgrowth promoting activates of these molecules. Neurocan is synthesized with a 22 aa signal peptide that is subsequently cleaved to produce the mature form. Neurocan contains one C-type lectin domain, two EGF-like domains, one Ig-like V type domain, two link domains and one Sushi (CCP/SCR) domain. (Ref.: Rauch, U., et al. (2001) Cell Mol. Life Sci. 58(12-13):1842-56; Zhou, XH et al. (2001). Mol. Cell Biol. 21(17): 5970-78).
References
Product Information
FormatUnpurified
PresentationRabbit polyclonal antiserum with 0.05% sodium azide.
Applications
ApplicationThis rabbit polyclonal Anti-Neurocan, Cat. No. ABT1382, is a rabbit polyclonal antibody that detects Neurocan core protein and has been tested for use in Immunofluorescence.
Key Applications
  • Immunofluorescence
Biological Information
ImmunogenFull-length Neurocan isolated from 7-day embryonic rat brain and purified by monoclonal antibody immunoaffinity chromatography.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis rabbit polyclonal antibody detects Neurocan in fetal and adult rat brain.
IsotypeIgG
Species Reactivity
  • Rat
Species Reactivity NoteRat.
Antibody TypePolyclonal Antibody
Gene Symbol
  • Ncan
  • Cspg3
Purification MethodUnpurified
UniProt Number
Molecular Weight135.55 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunofluorescence in E14 embryonic rat brain (frozen sections) and adult rat brain (frozen sections).

Immunofluorescence Analysis: A 1:500 dilution of this antibody detected Neurocan in E14 embryonic rat brain (frozen sections) and rat E14 neocortex.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Packaging Information
Material Size25 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
ABT1382-25UL 04054839512452

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