Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

AB10130 Anti-NR1D1 (Rev-ErbA α) Antibody

Anti-NR1D1 (Rev-ErbA α) Antibody is a Rabbit Polyclonal Antibody for detection of NR1D1 (Rev-ErbA α) also known as V-erbA-related protein EAR-1 & has been validated in WB.

Anti-NR1D1 (Rev-ErbA α) Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: EAR1, HREV, Rev-ErbAalpha , Rev-erbA-alpha , THRA1, THRAL, ear-1, hRev UniProt Number: P20393
AB10130
100 µg  
Purchase on Sigma-Aldrich

Offres spéciales

Aperçu

Replacement Information

Offres spéciales

100% Performance Guaranteed

Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB10130
DescriptionAnti-NR1D1 (Rev-ErbA α) Antibody
Alternate Names
  • V-erbA-related protein EAR-1
  • nuclear receptor subfamily 1, group D, member 1
  • thyroid hormone receptor, alpha-like
Background InformationRev-ErbA alpha (NR1D1 or nuclear receptor subfamily 1, group D, member 1), is a member of the Rev-ErbA family of nuclear receptors and is a transcriptional repressor. In mammals, Rev-Erbα is highly expressed in the liver, skeletal muscle, adipose tissue, and the brain, participating in the development and circadian regulation of these tissues. Rev-Erbα regulates gene transcription by directly binding to target response elements (RevREs), comprises an A/T-rich flank followed by AGGTCA. Rev-Erbα mediates repression by recruiting the corepressor N-CoR, which then activates the histone deacetylase (HDAC) 3. A number of target genes has been identified for Rev-Erbα, including the lipoproteins ApoA1 and ApoCIII, hydratase dehydrogenase, the circadian factor BMAL, and the anti-fibrinolytic factor PAI-1. Many of these genes are coordinately regulated by Rev-erbα and the RAR-related orphan receptor RORα, which share the same response elements but exert opposite effects on gene transcription. Crosstalk between Rev-Erbα and RORα likely acts to fine-tune of their target physiologic networks, such as circadian rhythms, metabolic homeostasis, and inflammation.
References
Product Information
FormatAffinity Purified
Control
  • A431 cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-NR1D1 (Rev-ErbA α) Antibody is a Rabbit Polyclonal Antibody for detection of NR1D1 (Rev-ErbA α) also known as V-erbA-related protein EAR-1 & has been validated in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to residues surrounding the area near the N-terminus region of NR1D1.
EpitopeNear N-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes NR1D1 near the N-terminus.
Species Reactivity
  • Human
Species Reactivity NoteProven to react with human.
Mouse and rat (92% sequence homology).
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • EAR1
  • HREV
  • Rev-ErbAalpha
  • Rev-erbA-alpha
  • THRA1
  • THRAL
  • ear-1
  • hRev
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine.
SUBUNIT STRUCTURE: Interacts with C1D By similarity.
SUBCELLULAR LOCATION: Nucleus Potential.
TISSUE SPECIFICITY: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines.
DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Molecular Weight~67 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in A431 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected NR1D1 in 10 µg of A431 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C for 1 year from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
AB10130 04053252620393

Documentation

Anti-NR1D1 (Rev-ErbA α) Antibody FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-NR1D1 (Rev-ErbA α) Antibody Certificats d'analyse

TitreNuméro de lot
Anti-NR1D1 (Rev-ErbA ) - NG1630774 NG1630774
Anti-NR1D1 (Rev-ErbA ) - NG1905694 NG1905694
Anti-NR1D1 (Rev-ErbA α) - 2389523 2389523
Anti-NR1D1 (Rev-ErbA α) - 2395704 2395704
Anti-NR1D1 (Rev-ErbA α) - 2428871 2428871
Anti-NR1D1 (Rev-ErbA α) - 2459519 2459519
Anti-NR1D1 (Rev-ErbA α) - 3703185 3703185
Anti-NR1D1 (Rev-ErbA α) -2763858 2763858
Anti-NR1D1 (Rev-ErbA α) -2859500 2859500
Anti-NR1D1 (Rev-ErbA α) Polyclonal Antib 2978906