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ABE1404 Anti-MAFA Antibody

This Anti-MAFA Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of MAFA.

Anti-MAFA Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: MAFA UniProt Number: Q8NHW3
ABE1404
100 µg  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE1404
DescriptionAnti-MAFA Antibody
Alternate Names
  • Transcription factor MafA
  • Pancreatic beta-cell-specific transcriptional activator
  • Transcription factor RIPE3b1
  • V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
Background InformationMAFA is a tissue specific transcription factor found in the nuclei of pancreas islet beta cells. MAFA specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. MAFA also cooperates synergistically with NEUROD1 and PDX1 in enhancing additional gene expression during development as well. Phosphorylation by GSK3 increases MAFA transcriptional activity and is required for its oncogenic activity. MAFA can be either an oncogene or act as a tumor suppressor, depending on the cell context.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-MAFA Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of MAFA.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: A 1:500 dilution from a representative lot was reported to detect MAFA in HeLa, 293T/17, Capan-2, SAOS-2, SH-SY5Y, and Skin 3, 44 cells.
Biological Information
ImmunogenMixture of three linear peptides corresponding to amino acids 1-150 of human MAFA.
EpitopeRegion near the N-terminus of MAFA
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityRecognizes MAFA
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • MAFA
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~ 35 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in a HEK293T cell lysate.

Western Blotting Analysis: A 1 µg/mL dilution of this antibody detected MAFA in a 293T cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
ABE1404 04055977051988