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ABE1800-25UG Anti-La-Related Protein 1

Anti-La-Related Protein 1 Antibody, Cat. No. ABE1800-25UG, is a highly specific rabbit polyclonal antibody, that targets La-related protein 1 and has been tested in Western Blotting and Immunocytochemistry and Immunohistochemistry (Paraffin).

Anti-La-Related Protein 1 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Epigenetics & Nuclear Function Gene Symbol: LARP1, KIAA0731, LARP UniProt Number: Q6PKG0
ABE1800-25UG
25 μg  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICC, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE1800-25UG
DescriptionAnti-La-Related Protein 1
Alternate Names
  • La ribonucleoprotein domain family member 1
Background InformationLa-related protein 1 (UniProt: Q6PKG0; also known as La ribonucleoprotein domain family member 1) is encoded by the LARP1 (also known as KIAA0731, LARP) gene (Gene ID: 23367) in human. La-related protein 1 is a cytoplasmic RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. It contains 1 HTH La-type RNA-binding domain and it associates with the mRNA 5'cap in an mTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. La-related protein 1 is also shown to associates with actively translating ribosomes via interaction with polyadenylate-binding protein 1 (PABPC1/PABP) and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. It is shown to be up-regulated in a number of hepatocellular carcinoma cell lines and liver cancer lesions, as well as in patients with hepatocellular carcinoma with a lower survival rate. (Ref.: Fonseca, BD et al. (2015). J. Biol. Chem. 290(26):15996-6020).
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-La-Related Protein 1 Antibody, Cat. No. ABE1800-25UG, is a highly specific rabbit polyclonal antibody, that targets La-related protein 1 and has been tested in Western Blotting and Immunocytochemistry and Immunohistochemistry (Paraffin).
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry (Paraffin)
Application NotesImmunocytochemistry Analysis: A 1:50 dilution from a representative lot detected La-Related Protein 1 in HEK293 cells.

Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected La-Related Protein 1 in human cerebellum, human tonsil, and human pancreas tissues.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 15 amino acids from the N-termnal half of huamn La-related protein 1.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypePolyclonal Antibody
Gene Symbol
  • LARP1
  • KIAA0731
  • LARP
Purification MethodAffinity Purified
UniProt Number
Molecular Weight123 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected La-Related Protein 1 in 10 µg of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
ABE1800-25UG 04054839453748