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ABC822 Anti-LIMP II Antibody

Anti-LIMP II Antibody is an antibody against LIMP II for use in western blotting, IHC & immunofluorescence.

Anti-LIMP II Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: SCARB2, CD36L2, LIMPII UniProt Number: Q14108
ABC822
100 µg  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC822
DescriptionAnti-LIMP II Antibody
Alternate Names
  • Lysosome membrane protein 2
  • 85 kDa lysosomal membrane sialoglycoprotein
  • LGP85
  • CD36 antigen-like 2
  • Lysosome membrane protein II
  • LIMP II
  • Scavenger receptor class B member 2
  • CD36
Background InformationLysosome membrane protein 2, also known as 85 kDa lysosomal membrane sialoglycoprotein (LGP85) or Lysosome membrane protein II (LIMP II) or Scavenger receptor class B member 2, and encoded by the gene name SCARB2 or CD36L2 or LIMPII, is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP II in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP II was shown to act as a receptor to bind β-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP II-deficient mice showed missorted as well as secreted β-glucocerebrosidase, suggesting that LIMP II also functions as the mannose-6-phosphate-independent trafficking receptor.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-LIMP II Antibody is an antibody against LIMP II for use in western blotting, IHC & immunofluorescence.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunofluorescence
Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected LIMP II in human skeletal muscle tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected LIMP II in human skeletal muscle cells.
Biological Information
ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human LIMP II.
Epitopecenter region
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • SCARB2
  • CD36L2
  • LIMPII
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~80 kDa observed. Despite its predicted molecular weight, LIMP II runs at approximately 80 – 85 kDa in Western Blotting.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human skeletal muscle tissue lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected GPAT-1 in human skeletal muscle tissue lysate with and without blocking peptide.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
ABC822 04053252943836