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ABC470 Anti-Kallikrein-5 Antibody/KLK5

This Anti-Kallikrein-5 Antibody/KLK5 is validated for use in Western Blotting and Immunohistochemistry for the detection of Kallikrein-5/KLK5.

Anti-Kallikrein-5 Antibody/KLK5 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: KLK5, SCTE UniProt Number: Q9Y337
ABC470
100 µg  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC470
DescriptionAnti-Kallikrein-5 Antibody/KLK5
Alternate Names
  • Kallikrein-5
  • Kallikrein-like protein 2
  • KLK-L2
  • Stratum corneum tryptic enzyme
  • Kallikrein-5/KLK5
Background InformationKallikrein-5/KLK5, or also known as Kallikrein-related peptidase 5, Kallikrein-like protein 2, KLK-L2, and formerly known as Stratum corneum tryptic enzyme (SCTE), is an important enzyme encoded by the gene KLK5/KLK-L2/SCTE. KLK5 is a secreted serine protease enzyme that is expressed in many tissues including the skin, breast and brain. In the skin, Kallikreins-related peptidases (KLKs) are proteases that are important for the desquamation process of the skin (cell shedding). KLK5 is considered as one of the most important KLKs in skin desquamation because KLK5 also regulates the activation of other Kallikreins needed for cell shedding. In disease, KLK5 displays aberrant expression in many cancers. However, expression of KLK5 in some cancer cells appears to suppress tumor growth and activity via reduced RhoA activity and the modulation the mevalonate pathway. This is particularly true in breast cancer and efforts are examining methods to increase KLK5 expression in breast cancer as a form of treatment.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Kallikrein-5 Antibody/KLK5 is validated for use in Western Blotting and Immunohistochemistry for the detection of Kallikrein-5/KLK5.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein-5/KLK5 in human skin cancer sections tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the Peptidase S1 domain of human Kallikrein-5/KLK5.
EpitopePeptidase S1 domain
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
  • Mouse
Species Reactivity NoteHuman, Mouse. Predicted to react with Chimpanzee, Gorilla based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • KLK5
  • SCTE
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~32 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in ovcar 3 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Kallikrein-5/KLK5 in 10 µg of ovcar 3 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
ABC470 04053252979415