Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABT356 Anti-Integrin alpha6 Antibody, clone 6H7.1

This Anti-Integrin alpha6 Antibody, clone 6H7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Integrin alpha6.

Anti-Integrin alpha6 Antibody, clone 6H7.1 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: ITGA6 UniProt Number: P23229
MABT356
100 μg  
Purchase on Sigma-Aldrich

Offres spéciales

Aperçu

Replacement Information

Offres spéciales

100% Performance Guaranteed

Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABT356
DescriptionAnti-Integrin alpha6 Antibody, clone 6H7.1
Alternate Names
  • Integrin alpha-6
  • CD49 antigen-like family member F
  • VLA-6
  • CD49f
Background InformationIntegrin alpha-6 (UniProt P23229; also known as CD49 antigen-like family member F, CD49f, Integrin alpha6B, VLA-6) is encoded by the ITGA6 (also known as ITGA6B) gene (Gene ID 3655) in human. The biological functions attributed to cell-extracellular matrix (ECM) interactions are mediated primarily by integrin family transmembrane receptors. A total of 18 alpha and 8 beta integrins have been identified in human. Each alpha integrin pairs up with one beta integrin non-covalently to form a functional heterodimeric dimer. At least 24 distinct integrin heterodimers are known with varying ligand specificities. For example, the alpha6-beta1 integrin is reported to mediate the spreading and laminin-binding of Schwann cells, while the alpha6-beta4 integrin is shown to play a role in the suppression of anoikis in human intestinal epithelial cells (IECs).

Signal (1-23), Integrin alpha-6 (24-1130). Processed into Integrin alpha-6 heavy chain (24 – 938), Integrin alpha-6 light chain (942-1130), Processed integrin alpha-6 (Alpha6p; 636 – 1130)
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Integrin alpha6 Antibody, clone 6H7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Integrin alpha6.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Integrin alpha6 in human skin tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic region of human Integrin alpha6 isoforms 2/4/6/7/9.
EpitopeCytoplasmic region of isoforms 2/4/6/7/9
Clone6H7.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityExpected to react with Integrin alpha-6 spliced isoforms 2 (Alpha-6X1A), 4 (Alpha-6X2A ), 6 (Alpha-6X1X2A), 7, and 9, as well as their respective proforms, cleaved light chains, and processed integrin alpha-6 forms (Alpha6p). Epitope is not present in isoform 1 (Alpha-6X1X2B), 3 (Alpha-6X1B), or 5 (Alpha-6X2B).
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ITGA6
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~140 kDa observed. Due to glycosylation, the target band(s) appears larger than the calculated 106.6 to 124.0 kDa based on the proform sequences of isoforms 2/4/6/7/9. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in SW480 human colon cancer cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Integrin alpha6 in 10 µg of SW480 human colon cancer cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
MABT356 04055977277036

Documentation

Anti-Integrin alpha6 Antibody, clone 6H7.1 FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-Integrin alpha6 Antibody, clone 6H7.1 Certificats d'analyse

TitreNuméro de lot
Anti-Integrin alpha6, clone 6H7.1 - 3330363 3330363
Anti-Integrin alpha6, clone 6H7.1 - 4069737 4069737
Anti-Integrin alpha6, clone 6H7.1 -Q2595862 Q2595862

Informations techniques

Titre
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.

Produits & Applications associés

Related Products

Référence Description
CBL458 Anti-CD49f Antibody, clone 4F10
CBL458F Anti-CD49f Antibody, FITC conjugated, clone 4F10, FITC conjugated
CBL458P Anti-CD49f Antibody, clone 4F10, Phycoerythrin conjugated
MAB13444 Anti-Integrin α6 Antibody, clone BnC6B4
MAB1358 Anti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4
MAB1378 Anti-Integrin α6 Antibody, clone NKI-GoH3
MAB1982 Anti-Integrin α6 Antibody, clone MA6

Catégories

Life Science Research > Antibodies and Assays > Primary Antibodies