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MAB1953 Anti-Integrin αV Antibody, clone P3G8

MAB1953
100 µg  
Purchase on Sigma-Aldrich

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Aperçu

Replacement Information

Offres spéciales

Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HELISA, FC, IP, ICC, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB1953
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Integrin αV Antibody, clone P3G8
Alternate Names
  • CD51
References
Product Information
FormatPurified
Quality LevelMQ100
Applications
ApplicationAnti-Integrin αV Antibody, clone P3G8 is an antibody against Integrin αV for use in ELISA, FC, IP, IC, IH.
Key Applications
  • ELISA
  • Flow Cytometry
  • Immunoprecipitation
  • Immunocytochemistry
  • Immunohistochemistry
Application NotesImmunohistochemistry: 1:1,000. For use on acetone or paraformaldehyde fixed tissue

Immunocytochemistry: 1:1,000. Will react with some lymphoid cell lines (B cells), many carcinoma and melanoma cell lines and osteosarcomas.

Flow cytometry

Immunoprecipitation

FACS

EIA

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenUCLA P3 lung carcinoma cells
CloneP3G8
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityReacts with human alphaV integrin subunit and with all alphaV-containing integrin receptors.
IsotypeIgG1
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
Gene Symbol
  • ITGAV
  • DKFZp686A08142
  • MSK8
  • CD51
  • VNRA
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
MAB1953 04053252268045

Documentation

Anti-Integrin αV Antibody, clone P3G8 FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-Integrin αV Antibody, clone P3G8 Certificats d'analyse

TitreNuméro de lot
MOUSE ANTI-HUMAN INTEGRIN aV MONOCLONAL ANTIBODY - 2064707 2064707
MOUSE ANTI-HUMAN INTEGRIN αV - 3217097 3217097
MOUSE ANTI-HUMAN INTEGRIN αV - 3465455 3465455
MOUSE ANTI-HUMAN INTEGRIN αV - 3552707 3552707
MOUSE ANTI-HUMAN INTEGRIN αV - 3864954 3864954
MOUSE ANTI-HUMAN INTEGRIN αV - 3976638 3976638
MOUSE ANTI-HUMAN INTEGRIN αV - 4090665 4090665
MOUSE ANTI-HUMAN INTEGRIN αV MONOCLONAL AN 2880999
MOUSE ANTI-HUMAN INTEGRIN V -2799088 2799088
MOUSE ANTI-HUMAN INTEGRIN V -2809275 2809275

Références bibliographiques

Aperçu de la référence bibliographiqueNº PubMed
Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy.
Sallach, J; Di Pasquale, G; Larcher, F; Niehoff, N; Rübsam, M; Huber, A; Chiorini, J; Almarza, D; Eming, SA; Ulus, H; Nishimura, S; Hacker, UT; Hallek, M; Niessen, CM; Büning, H
Molecular therapy : the journal of the American Society of Gene Therapy  22  929-39  2014

Afficher le résumé
24468915 24468915
Mannose 6-phosphate/insulin-like growth factor 2 receptor limits cell invasion by controlling alphaVbeta3 integrin expression and proteolytic processing of urokinase-type plasminogen activator receptor.
Schiller, HB; Szekeres, A; Binder, BR; Stockinger, H; Leksa, V
Molecular biology of the cell  20  745-56  2009

Afficher le résumé Article en texte intégral
19037107 19037107
Wettability of substrata controls cell-substrate and cell-cell adhesions.
R Tzoneva,N Faucheux,T Groth
Biochimica et biophysica acta  1770  2007

Afficher le résumé
17804166 17804166
Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer.
Rentsendorj, A; Xie, J; MacVeigh, M; Agadjanian, H; Bass, S; Kim, DH; Rossi, J; Hamm-Alvarez, SF; Medina-Kauwe, LK
Gene therapy  13  821-36  2005

Afficher le résumé
16482205 16482205
Integrins modulate fast excitatory transmission at hippocampal synapses.
Kramár, EA; Bernard, JA; Gall, CM; Lynch, G
The Journal of biological chemistry  278  10722-30  2003

Afficher le résumé
12524441 12524441
Developmental and regional differences in the consolidation of long-term potentiation.
E A Kramár, G Lynch
Neuroscience  118  387-98  2003

Afficher le résumé
12699775 12699775
Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.
Weinacker, A, et al.
J. Biol. Chem., 269: 6940-8 (1994)  1993

Afficher le résumé
8120056 8120056

Fiche technique

Titre
MOUSE ANTI-HUMAN INTEGRIN alphaV

Produits & Applications associés

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Alternative Format

Référence Description
MAB1953Z Anti-Integrin αV Antibody, clone P3G8, azide free

Catégories

Life Science Research > Antibodies and Assays > Primary Antibodies