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AB15157 Anti-Ghrelin Antibody, active & proform

This Anti-Ghrelin Antibody, active & proform is validated for use in WB for the detection of Ghrelin.

Anti-Ghrelin Antibody, active & proform : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: CNS Control of Metabolism Gene Symbol: GHRL, ghrelin, obestatin, MTLRP UniProt Number: Q9UBU3
AB15157
100 µL  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB15157
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Ghrelin Antibody, active & proform
References
Product Information
FormatSerum
PresentationLiquid.
Quality LevelMQ100
Applications
ApplicationThis Anti-Ghrelin Antibody, active & proform is validated for use in WB for the detection of Ghrelin.
Key Applications
  • Western Blotting
Application NotesWestern blot: 1:5,000-1:10,000 on extracts from mouse stomach.

Optimal working dilutions must be determined by the end user.
Biological Information
HostRabbit
SpecificityGhrelin, active & proform. By Western blot the antibody recognizes a band at ~13 kDa using mouse stomach lysate. The band is completed abolished after incubating the antibody with the immunogen peptide.
Species Reactivity
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryGhrelin is an endogenous ligand for the growth hormone secretagogue receptor (GHSR; MIM 601898) and is involved in regulating growth hormone (GH; MIM 139250) release. Ghrelin is derived from a preprohormone called preproghrelin, which also generates a second peptide called obestatin. Obestatin is an endogenous ligand for the orphan G protein-coupled receptor GPR39 (MIM 602886) and is involved in satiety and decreased food intake.[supplied by OMIM]
Gene Symbol
  • GHRL
  • ghrelin
  • obestatin
  • MTLRP
Purification MethodSerum
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9UBU3 # Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
SIZE: 117 amino acids; 12911 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
AB15157 04053252338922