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ABN1377 Anti-GPR98 Antibody

Anti-GPR98 Antibody is an antibody against GPR98 for use in Immunohistochemistry.

Anti-GPR98 Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: GPCR, cAMP/cGMP & Calcium Signaling Gene Symbol: GPR98, KIAA0686, KIAA1943, MASS1, USH2C, VLGR1 UniProt Number: Q8WXG9
ABN1377
100 μg  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN1377
DescriptionAnti-GPR98 Antibody
Alternate Names
  • G-protein coupled receptor 98
  • Monogenic audiogenic seizure susceptibility protein 1 homolog
  • Usher syndrome type-2C protein
  • Very large G-protein coupled receptor 1
Background InformationG-protein coupled receptor 98 (UniProt Q8WXG9; also known as Monogenic audiogenic seizure susceptibility protein 1 homolog, Usher syndrome type-2C protein, Very large G-protein coupled receptor 1) is encoded by the GPR98 (also known as KIAA0686, KIAA1943, MASS1, USH2C, VLGR1) gene (Gene ID 84059) in human. GPR98, also known as Very Large GPCR receptor 1 (Vlg1R1), is the largest G-protein-coupled receptor (GPCR) known. It is an adhesion-GPCR family receptor expressed in the central nervous system. GPR98 is produced with a signal peptide (a.a. 1-29) sequence, the removal of which yields the mature seven-transmembrane (a.a. 5909-5929, 5940-5960, 5980-6000, 6011-6031, 6060-6080, 6105-6125, 6134-6154) protein with a C-termiinal cytoplasmic domain (a.a. 6155-6306) and a large N-terminal extracellular region (a.a. 30-5908) that contains six epilepsy-associated repeats or EAR domains (a.a. 3189-3534) sandwiched between two clusters of calcium-binding Calx-beta repeats (Calx-beta 1-22/a.a. 30-3172 and Calx-beta 23-35/a.a. 3525-5468), as well as a GPCR-proteolytic site (GPS; a.a. 5853-5902) proximal to the first transmembrane helix. The extreme carboxy-terminus contains a consensus PDZ ligand sequence, suggesting interactions with other cytosolic or cytoskeletal proteins. Although the GPR98 ligand is yet to be identified, GPR98 gene mutations are linked to one form (2C) of Usher syndrome, the most common genetic cause of combined blindness and deafness.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-GPR98 Antibody is an antibody against GPR98 for use in Immunohistochemistry.
Key Applications
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected GPR98 in human cochlea tissue sections.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to a sequence from the second Calx-beta repeat of human GPR98.
EpitopeCalx-beta repeat 2.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityExpected to react with spliced isoform 1 (VLGR1b), isoform 3 (VLGR1c), and isoform 4, but not isoform 2 (VLGR1a) of human GPR98 reported by UniProt (Q8WXG9).
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with non-human primates based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • GPR98
  • KIAA0686
  • KIAA1943
  • MASS1
  • USH2C
  • VLGR1
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight690.1 kDa (isoform 1; VLGR1b), 249.9 kDa (isoform 3; VLGR1c), and 159.1 kDa (isoform 4) calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human retina tissue.

Immunohistochemistry Analysis: An 1:50 dilution of this antibody detected GPR98 in human retina tissue sections.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
ABN1377 04055977332292