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ABC227-25UL Anti-GABARAPL2

Anti-GABARAPL2, Cat. No. ABC227, is a rabbit polyclonal antibody that detects Gamma-aminobutyric acid receptor-associated protein-like 2 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-GABARAPL2 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Apoptosis & Cancer Gene Symbol: GABARAPL2, FLC3A, GEF2 UniProt Number: P60520
ABC227-25UL
25 µL  
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Replacement Information

Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC227-25UL
DescriptionAnti-GABARAPL2
Alternate Names
  • Gamma-aminobutyric acid receptor-associated protein-like 2
  • GABA(A) receptor-associated protein-like 2
  • Ganglioside expression factor 2
  • GEF-2
  • General protein transport factor p16
  • Golgi-associated ATPase enhancer of 16 kDa
  • GATE-16
  • MAP1 light chain 3-related protein
Background InformationGamma-aminobutyric acid receptor-associated protein-like 2 (UniProt: P60520; also known as GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, GEF-2, General protein transport factor p16, Golgi-associated ATPase enhancer of 16 kDa, GATE-16, MAP1 light chain 3-related protein) is encoded by the GABARAPL2 (also known as FLC3A, GEF2) gene (Gene ID: 11345) in human. GEF-2 is a momomeric ubiquitin-like modifier protein of ATG8 family that is involved in intra-Golgi traffic. It is shown to modulate intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF, which in turn stimulates the association with GOSR1. GEF-2 is also involved in autophagy and plays a role in mitophagy, which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level. It is ubiquitously expressed and higher expressions are observed in the brain, heart, prostate, ovary, spleen and skeletal muscle. Low expression levels are observed in lung, thymus, and small intestine. In the precursor molecule the peptide bond between aa 116 and 117 is cleaved off by ATG4 to generate mature protein.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide/.
Applications
ApplicationAnti-GABARAPL2, Cat. No. ABC227, is a rabbit polyclonal antibody that detects Gamma-aminobutyric acid receptor-associated protein-like 2 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected GABARAPL2 in human cerebellum and human prostate tissue sections.
Biological Information
ImmunogenGST-tagged full length human recombinant GABA(A) receptor-associated protein-like 2 (GABARAPL2).
Epitopeunknown
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis rabbit polyclonal antibody detects GABA(A) receptor-associated protein-like 2 (GABARAPL2) in human cells.
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypePolyclonal Antibody
Gene Symbol
  • GABARAPL2
  • FLC3A
  • GEF2
Purification MethodAffinity Purified
UniProt Number
Molecular Weight~ 14 kDa observed; 13.67 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Raji membrane extract.

Western Blotting Analysis: A 1:500 dilution of this antibody detected GABARAPL2 in Raji membrane extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
ABC227-25UL 04054839482137