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16-234 Sigma-AldrichAnti-FAK Antibody, clone 4.47, Alexa Fluor® 555 conjugate

Anti-FAK Antibody, clone 4.47, Alexa Fluor 555 conjugate detects level of FAK & has been published & validated for use in FC, WB & IC.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

FDS
CoA
Références bibliographiques

Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: PTK2, pp125FAK, FADK, FAK1, FAK UniProt Number: Q05397

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Tableau de caractéristiques principal

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R	FC, WB, ICC	M	AlexaFluor®555	Monoclonal Antibody

Description
Catalogue Number	16-234
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-FAK Antibody, clone 4.47, Alexa Fluor® 555 conjugate

References

Product Information
Format	AlexaFluor®555
Quality Level	MQ100

Applications
Application	Anti-FAK Antibody, clone 4.47, Alexa Fluor 555 conjugate detects level of FAK & has been published & validated for use in FC, WB & IC.
Key Applications	Flow Cytometry Western Blotting Immunocytochemistry

Biological Information
Immunogen	GST fusion protein corresponding to residues 1-423 of human FAK (focal adhesion kinase)
Clone	clone 4.47
Host	Mouse
Specificity	p125FAK, does not cross react with Pyk-2
Isotype	IgG1
Species Reactivity	Human Mouse Rat
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_005607.3 NM_153831.2
Entrez Gene Summary	This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined.
Gene Symbol	PTK2 pp125FAK FADK FAK1 FAK
Purification Method	Protein G Purified
UniProt Number	Q05397
UniProt Summary	FUNCTION: SwissProt: Q05397 # Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. SIZE: 1052 amino acids; 119233 Da SUBUNIT: Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with SHB (By similarity). Interacts with TGFB1I1. SUBCELLULAR LOCATION: Cell junction, focal adhesion; Cytoplasmic side. Note=Constituent of focal adhesions. TISSUE SPECIFICITY: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain. DOMAIN: SwissProt: Q05397 The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL (By similarity). & The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions. PTM: Phosphorylated on 6 tyrosine residues upon activation. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain.
Molecular Weight	125kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by immunostaining in 3T3 cells
Usage Statement	Alexa Fluor® is a registered trademark of Molecular Probes, Inc. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Product Usage Statements

Quality Assurance

Routinely evaluated by immunostaining in 3T3 cells

Usage Statement

Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	1 year at 4°C from date of shipment

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Référence	GTIN
16-234	04053252470844

Documentation

Anti-FAK Antibody, clone 4.47, Alexa Fluor® 555 conjugate FDS

Titre
Fiche de données de sécurité des matériaux (FDS)

Anti-FAK Antibody, clone 4.47, Alexa Fluor® 555 conjugate Certificats d'analyse

Titre	Numéro de lot
Anti-FAK, clone 4.47, Alexa Fluor#174; 555 conjugate - DAM1432877	DAM1432877
Anti-FAK, clone 4.47, Alexa Fluorreg; 555 conjugate - 30488	30488
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate (mouse monoclonal IgG1)	3074352
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate (mouse monoclonal IgG1)	2900701
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate (mouse monoclonal IgG1) - 2251743	2251743
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate - 3429411	3429411
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate - 3823361	3823361
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate - 4107775	4107775
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate - 4133053	4133053
Anti-FAK, clone 4.47, Alexa Fluor® 555 conjugate -2616232	2616232

Références bibliographiques

Aperçu de la référence bibliographique	Nº PubMed
Advances in high content screening for drug discovery. Giuliano, Kenneth A, et al. Assay and drug development technologies, 1: 565-77 (2003) 2003	15090253

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Alternative Format

Référence	Description
05-537	Anti-FAK Antibody, clone 4.47
16-173	Anti-FAK Antibody, clone 4.47, agarose conjugate
16-233	Anti-FAK Antibody, clone 4.47, Alexa Fluor® 488 conjugate

Catégories

Life Science Research > Antibodies and Assays > Primary Antibodies

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