Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

07-735 Anti-CENP-B Antibody

Anti-CENP-B Antibody is a Rabbit Polyclonal Antibody for detection of CENP-B also known as Centromere autoantigen B & has been tested in WB.

Anti-CENP-B Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Cell Cycle, DNA Replication & Repair Gene Symbol: CENPB, CENP-B UniProt Number: P07199
07-735
100 µg  
Purchase on Sigma-Aldrich

Offres spéciales

Aperçu

Replacement Information

Offres spéciales

100% Performance Guaranteed

Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbPurifiedPolyclonal Antibody
Description
Catalogue Number07-735
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-CENP-B Antibody
References
Product Information
FormatPurified
Quality LevelMQ100
Applications
ApplicationAnti-CENP-B Antibody is a Rabbit Polyclonal Antibody for detection of CENP-B also known as Centromere autoantigen B & has been tested in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenBeta galactosidase fusion protein of human CENP-B.
HostRabbit
SpecificityBeta galactosidase fusion protein of human CENP-B.
IsotypeIgG
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
Gene Symbol
  • CENPB
  • CENP-B
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P07199 # Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
SIZE: 599 amino acids; 65171 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: SwissProt: P07199 ## Contains 1 HTH CENPB-type DNA-binding domain. & Contains 1 HTH psq-type DNA-binding domain.
Molecular Weight80kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C from date of shipment
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
07-735 04053252470059