Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

CBL714 Anti-CD126 Antibody, clone B-R6

This Anti-CD126 Antibody, clone B-R6 is validated for use in ELISA, FC, IP, IH for the detection of CD126.

Anti-CD126 Antibody, clone B-R6 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: IL6R, MGC104991, IL-6R-alpha, IL6RA, CD126, gp80, IL-6R-1 UniProt Number: P08887
CBL714
100 µg  
Purchase on Sigma-Aldrich

Offres spéciales

Aperçu

Replacement Information

Offres spéciales

100% Performance Guaranteed

Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HELISA, FC, IP, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberCBL714
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-CD126 Antibody, clone B-R6
Alternate Names
  • IL-6 Receptor, alpha Chain
References
Product Information
FormatPurified
PresentationThe monoclonal was purified by ion exchange chromatography and is presented as a liquid in phosphate buffered saline, pH 7.4, containing 0.09% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-CD126 Antibody, clone B-R6 is validated for use in ELISA, FC, IP, IH for the detection of CD126.
Key Applications
  • ELISA
  • Flow Cytometry
  • Immunoprecipitation
  • Immunohistochemistry
Application NotesFlow cytometry: 1:50. Use 10 μL of this dilution to label 10e6 cells in 100 μL.

Immunohistochemistry on frozen sections.

Immunoprecipitation.

ELISA

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenCHO cells transfected with a cDNA of the human IL-6 receptor.
CloneB-R6
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThis antibody recognizes both the soluble and membrane bound human IL-6 receptor. The antibody will inhibit IL-6 mediated proliferation of XG-1 cells and partially blocks the binding of IL-6 to its receptor.
IsotypeIgG1
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryInterleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene Symbol
  • IL6R
  • MGC104991
  • IL-6R-alpha
  • IL6RA
  • CD126
  • gp80
  • IL-6R-1
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P08887 # Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
SIZE: 468 amino acids; 51548 Da
SUBUNIT: Hexamer of two molecules each of IL6, IL6R and IL6ST.
SUBCELLULAR LOCATION: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
DOMAIN: SwissProt: P08887 The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain. & The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
PTM: A short soluble form may also be released from the membrane by proteolysis.
SIMILARITY: Belongs to the type I cytokine receptor family. Type 3 subfamily. & Contains 1 fibronectin type-III domain. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2°-8°C for up to 12 months from date of receipt in undiluted aliquots.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
CBL714 04053252471681

Documentation

Anti-CD126 Antibody, clone B-R6 FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-CD126 Antibody, clone B-R6 Certificats d'analyse

TitreNuméro de lot
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] MONOCLONAL ANTIBODY - 2116652 2116652
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] MONOCLONAL ANTIBODY - 2378748 2378748
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] - 3225736 3225736
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] - 3951346 3951346
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2550862 2550862
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2681167 2681167
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2696627 2696627
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2725221 2725221
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2767715 2767715
MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] MONOCLONAL ANTIBODY 3131823
Show more