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AB5613 Anti-Brain Derived Neurotrophic Factor Antibody, pro

Anti-Brain Derived Neurotrophic Factor Antibody, pro is an antibody proBDNF for use in Immunohistochemistry and Western Blotting.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Neurochemistry & Neurotrophins, Neuroinflammation & Pain Gene Symbol: BDNF UniProt Number: P23560
AB5613
50 µL  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RIHC, WBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB5613
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Brain Derived Neurotrophic Factor Antibody, pro
Alternate Names
  • Prepro-Abrineurin
  • Pro-Abrineurin
  • Prepro-BDNF
  • Pro-BDNF
  • Prepro-Brain-derived neurotrophic factor
  • Pro-Brain-derived neurotrophic factor
Background InformationBrain-derived neurotrophic factor (UniProt P23560; also known as Abrineurin, BDNF, Neurotrophin) is encoded by the BDNF (also known as BULN2) gene (Gene ID 627) in human. BDNF is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT3, and NT4/5. BDNF mediates its neurotrophic properties by signaling through the high affinity cell surface receptor gp145/trkB. BDNF is initially produced with a signal peptide (a.a. 1-18) and a propeptide (a.a. 19-128) sequence, the removal of which yields the mature BDNF (a.a. 129-247).
References
Product Information
FormatSerum
HS Code3002 15 90
PresentationRabbit serum. Lyophilized. Reconstitute with 50 μL of sterile distilled water.
Quality LevelMQ100
Applications
ApplicationAnti-Brain Derived Neurotrophic Factor Antibody, pro is an antibody proBDNF for use in Immunohistochemistry and Western Blotting.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application NotesWestern blot: 1:1,000-1:5,000

Immunohistochemistry: 1:1,000-1:5,000

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to a region within human BDNF propeptide sequence.
EpitopePropeptide.
HostRabbit
SpecificityThis polyclonal antiserum detects prepro- and pro-BDNF, as well as prepro-/pro-BDNF-derived N-terminal fragments that contain the propeptide sequence (a.a. 19-128), but not mature BDNF or C-terminal fragments without the propeptide sequence. No cross-reactivity to other proneurotrophins.
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • BDNF
UniProt Number
Molecular Weight~35 kDa (glycosylated prepro-/pro-BDNF), ~50-65 kDa (glycosylated prepro-/pro-BDNF dimer), and ~26-28 kDa (non-glycosylated prepro/pro-BDNF or glycosylated prepro-/pro-BDNF N-terminal fragments) observed. Target bands appear larger than the calculated molecular weights of 27.82/28.87/29.82/37.12/31.12 kDa (human prepro-BDNF isoform 1/2/3/4/5) and 25.77/26.82/27.77/35.07/29.06 kDa (human pro-BDNF isoform 1/2/3/4/5) due to glycosylation and/or dimerization. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain lyophilized material at -20°C for up to 6 months after date of receipt. After reconstitution maintain at -20°C undiluted for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (ACS grade or better) can be added (1:1) for additional stability.
Packaging Information
Material Size50 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
AB5613 04053252274855

Documentation

Anti-Brain Derived Neurotrophic Factor Antibody, pro FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Anti-Brain Derived Neurotrophic Factor Antibody, pro Certificats d'analyse

TitreNuméro de lot
RABBIT ANTI-proBDNF - 2539973 2539973
RABBIT ANTI-proBDNF - 3194638 3194638
RABBIT ANTI-proBDNF -2510130 2510130
RABBIT ANTI-proBDNF -2578093 2578093
RABBIT ANTI-proBDNF -2615698 2615698
RABBIT ANTI-proBDNF -2661300 2661300
RABBIT ANTI-proBDNF -2701577 2701577
RABBIT ANTI-proBDNF -2707205 2707205
RABBIT ANTI-proBDNF POLYCLONAL ANTIBODY - 2074748 2074748
RABBIT ANTI-proBDNF POLYCLONAL ANTIBODY - 2506277 2506277
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Références bibliographiques

Aperçu de la référence bibliographiqueNº PubMed
Progesterone treatment alters neurotrophin/proneurotrophin balance and receptor expression in rats with traumatic brain injury.
Milos Cekic,Sarah J Johnson,Vinay H Bhatt,Donald G Stein
Restorative neurology and neuroscience  30  2011

Afficher le résumé 		22232032 22232032

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Alternative Format

Référence Description
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Catégories

Life Science Research > Antibodies and Assays > Primary Antibodies