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AB15708A4 Anti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate

Anti-Beta III Tubulin Antibody, Alexa Fluor 488 Conjugate is an antibody against Beta III Tubulin for use in IC, IH.

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Research Category: Neuroscience Research Sub-Category: Neurofilament & Neuron Metabolism Gene Symbol: TUBB3, TUBB4, MC1R, beta-4 UniProt Number: Q13509
AB15708A4
100 µL  
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
R, M, HICC, IHCRbAlexaFluor®488Polyclonal Antibody
Description
Catalogue NumberAB15708A4
DescriptionAnti-Beta III Tubulin Antibody, Alexa Fluor® 488 Conjugate
Alternate Names
  • Tubulin beta-4
  • Tubulin beta-III
  • tubulin, beta 3
  • tubulin, beta, 4
Background InformationTubulin is one of several members of a small family of globular proteins which polymerize to form cytoskeletal structures called microtubules. The most common members of the tubulin family are α-tubulin and β-tubulin. Tubulin dimers, typically composed of α- and β-tubulin subunits, assemble onto microtubules forming large polymers. β-III tubulin is a unique microtubule subunit that is found expressed almost exclusively in neurons. Due to the unique expression pattern of β-III tubulin it is often utilized as a marker to identify neuronal cells from other brain cells such as glia which do not express it. β-III tubulin also serves as a cytoarchitectural marker since it is primarily found within neurite extensions.
Product Information
FormatAlexaFluor®488
Control
  • Rat E18 cortex cells
PresentationPurified rabbit polyclonal conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationAnti-Beta III Tubulin Antibody, Alexa Fluor 488 Conjugate is an antibody against Beta III Tubulin for use in IC, IH.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
Application NotesImmunohistochemistry: Representive lot has been shown to work in adult mouse brain.
Biological Information
ImmunogenSynthetic linear peptide corresponding to human Beta III Tubulin.
HostRabbit
SpecificityThis antibody recognizes Beta III Tubulin.
Species Reactivity
  • Rat
  • Mouse
  • Human
Species Reactivity NoteDemonstrated to react with Rat and Mouse. Predicted to react with Human based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
Gene Symbol
  • TUBB3
  • TUBB4
  • MC1R
  • beta-4
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.

SIZE: 450 amino acids; 50433 Da

SUBUNIT: Dimer of alpha and beta chains.

DOMAIN: The highly acidic C-terminal region may bind cations such as calcium.

SIMILARITY: Belongs to the tubulin family.
Molecular Weight50 kDa calculated
Product Usage Statements
Quality AssuranceEvaluated by Immunocytochemistry in rat E18 cortex cells.

Immunocytochemistry Analysis: A 1:400 dilution of this antibody detected Beta III Tubulin in rat E18 cortex cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Global Trade Item Number
Référence GTIN
AB15708A4 04053252754968