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06-680-AF488 Anti-Androgen Receptor Antibody, Alexa Fluor® 488 Conjugate

Detect Androgen Receptor using this Anti-Androgen Receptor Antibody, Alexa Fluor® 488 Conjugate validated for use in Immunocytochemistry.

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Uni Prot Number: P15207
06-680-AF488
100 µL  
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Tableau de caractéristiques principal

Uni Prot Number
P15207
Description
Catalogue Number06-680-AF488
DescriptionAnti-Androgen Receptor Antibody, Alexa Fluor® 488 Conjugate
Alternate Names
  • Androgen receptor
  • Dihydrotestosterone receptor
  • Nuclear receptor subfamily 3 group C member 4
Background InformationAndrogen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome.
References
Product Information
FormatAlexaFluor®488
PresentationPurified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Androgen Receptor using this Anti-Androgen Receptor Antibody, Alexa Fluor® 488 Conjugate validated for use in Immunocytochemistry.
Key Applications
  • Immunocytochemistry
Application NotesThe unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor.
EpitopeThis antibody recognizes the Modulating Region within the N-terminal of androgen receptor.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
  • Rat
Species Reactivity NoteHuman, Rat. Predicted to react with Mouse, Bovine, Horse, Canine based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Ar
  • Andr, Nr3c4
  • Tfm
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~110 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunocytochemistry in MCF-7 cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Androgen Receptor in MCF-7 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
06-680-AF488 04055977313154