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176695 Angeli’s Salt - CAS 13826-64-7 - Calbiochem

A nitroxyl anion (NO⁻) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound.

Angeli’s Salt - CAS 13826-64-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Sodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate

176695
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
13826-64-7N₂O₃ · 2Na

Products

RéférenceConditionnement Qté
176695-10MG Flacon en verre 10 mg
Description
OverviewA nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.
Catalogue Number176695
Brand Family Calbiochem®
SynonymsSodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate
References
ReferencesMiranda, K.M., et al. 2001. J. Biol. Chem. 276, 1720.
Hrinczenko, B.W., et al. 2000. Br. J. Haematol. 110, 412.
Nelli, S., et al. 2000. Br. J. Pharmacol. 131, 356.
Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14617.
Keefer, L.K., et al. 1996. Methods Enzymol. 268, 281.
Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 707.
Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.
Product Information
CAS number13826-64-7
ATP CompetitiveN
FormCrystalline solid
Hill FormulaN₂O₃ · 2Na
Chemical formulaN₂O₃ · 2Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNitroxyl anion (NO-) donor
Purity≥99%
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
176695-10MG 04055977222951

Documentation

Angeli’s Salt - CAS 13826-64-7 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Angeli’s Salt - CAS 13826-64-7 - Calbiochem Certificats d'analyse

TitreNuméro de lot
176695

Références bibliographiques

Aperçu de la référence bibliographique
Miranda, K.M., et al. 2001. J. Biol. Chem. 276, 1720.
Hrinczenko, B.W., et al. 2000. Br. J. Haematol. 110, 412.
Nelli, S., et al. 2000. Br. J. Pharmacol. 131, 356.
Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14617.
Keefer, L.K., et al. 1996. Methods Enzymol. 268, 281.
Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 707.
Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2018 JSW
SynonymsSodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate
DescriptionA nitroxyl anion (NO-) donor that spontaneously, in the presence of oxygen and Cu2+ and Fe3+, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC50 = 590 nM). Angeli's Salt produces nitroxyl anion (NO-) that can be converted to NO in the presence of heme.
FormCrystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number13826-64-7
Chemical formulaN₂O₃ · 2Na
Structure formulaStructure formula
Purity≥99%
SolubilityAlkaline solutions (0.01 M NaOH)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers.
Toxicity Standard Handling
ReferencesMiranda, K.M., et al. 2001. J. Biol. Chem. 276, 1720.
Hrinczenko, B.W., et al. 2000. Br. J. Haematol. 110, 412.
Nelli, S., et al. 2000. Br. J. Pharmacol. 131, 356.
Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14617.
Keefer, L.K., et al. 1996. Methods Enzymol. 268, 281.
Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 707.
Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.