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124020 Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

Akt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1.

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Synonymes: 10-DEBC HC, 10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP

Primary Target: Akt
124020
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Tableau de caractéristiques principal

CAS #Empirical Formula
925681-41-0C₂₀H₂₅ClN₂O • HCl

Products

RéférenceConditionnement Qté
124020-5MG Ampoule plast. 5 mg
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Description
OverviewA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039).
Catalogue Number124020
Brand Family Calbiochem®
Synonyms10-DEBC HC, 10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP
References
ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press.
Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
Product Information
CAS number925681-41-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₀H₂₅ClN₂O • HCl
Chemical formulaC₂₀H₂₅ClN₂O • HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationAkt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1.
Biological Information
Primary TargetAkt
Primary Target IC<sub>50</sub><5 µM against Akt ; 2-5 µM against growth of Rh (rhabdomyosarcoma) cell lines
Secondary targetRn cell lines (IC₅₀ = 2-5 µM)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
124020-5MG 04055977205749