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530729 AAA-ATPase Drg1 Inhibitor, Diazaborine - CAS 22959-81-5 - Calbiochem

An anti-bacterial compound that targets NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR) resulting in the inhibition of bacterial fatty acid synthase.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-tosylbenzo[d][1,2,3]diazaborinin-1(2H)-ol, Ribosome Biogenesis Inhibitor, Diazaborine, Drg1 inhibitor

Primary Target: Drg1 AAA-ATPase
530729
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Tableau de caractéristiques principal

CAS #Empirical Formula
22959-81-5C₁₄H₁₃BN₂O₃S

Products

RéférenceConditionnement Qté
5307290001 Flacon en verre 10 mg
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Description
OverviewA diazaborine derivative with anti-bacterial properties against a wide range of Gram-negative bacteria. Shown to target NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR), which results in the inhibition of bacterial fatty acid synthase. Blocks the maturation of ribosomal RNA for the large 60S ribosomal subunit in yeast cells by binding to the D2 domain of AAA-ATPase Drg1 (Ki = 26 µM) resulting in reduced ATP hydrolysis and release of Rip24 from pre-60S particles.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530729
Brand Family Calbiochem®
Synonyms2-tosylbenzo[d][1,2,3]diazaborinin-1(2H)-ol, Ribosome Biogenesis Inhibitor, Diazaborine, Drg1 inhibitor
References
ReferencesLoibl, M., et al. 2014. J. Biol. Chem. 289, 3913.
Pertschy B., et al. 2004. Mol. Cell. Biol. 24, 6476.
Baldock, C. et al. 1998. Biochem. Pharmacol. 55, 1541.
Grassberger M., et al. 1984. J Med Chem. 27, 947.
Product Information
CAS number22959-81-5
FormWhite powder
Hill FormulaC₁₄H₁₃BN₂O₃S
Chemical formulaC₁₄H₁₃BN₂O₃S
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetDrg1 AAA-ATPase
Primary Target K<sub>i</sub>26 µ
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
5307290001 04055977260458