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260585 5ʹ-Deoxy-5ʹ-methylthioadenosine - CAS 2457-80-9 - Calbiochem

A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: MTA, MeSAdo

260585
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
2457-80-9C₁₁H₁₅N₅O₃S

Products

RéférenceConditionnement Qté
260585-50MG Ampoule plast. 50 mg
Description
OverviewA cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.
Catalogue Number260585
Brand Family Calbiochem®
SynonymsMTA, MeSAdo
References
ReferencesLee, S.H., and Cho, Y.D. 1998. Exp. Cell Res. 240, 282.
Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res. 51, 53.
Joy, A., et al. 1997. Oncogene 14, 171.
Riscoe, M.K., et al. 1984. Biochem. Pharmacol. 33, 3639.
Product Information
CAS number2457-80-9
FormWhite solid
Hill FormulaC₁₁H₁₅N₅O₃S
Chemical formulaC₁₁H₁₅N₅O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetprotein carboxymethyltranferase
Secondary targetFGF-2receptor tyrosine kinase activity
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSAU7410000
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
260585-50MG 04055977217476

Documentation

5ʹ-Deoxy-5ʹ-methylthioadenosine - CAS 2457-80-9 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

5ʹ-Deoxy-5ʹ-methylthioadenosine - CAS 2457-80-9 - Calbiochem Certificats d'analyse

TitreNuméro de lot
260585

Références bibliographiques

Aperçu de la référence bibliographique
Lee, S.H., and Cho, Y.D. 1998. Exp. Cell Res. 240, 282.
Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res. 51, 53.
Joy, A., et al. 1997. Oncogene 14, 171.
Riscoe, M.K., et al. 1984. Biochem. Pharmacol. 33, 3639.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-July-2023 JSW
SynonymsMTA, MeSAdo
DescriptionA naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number2457-80-9
RTECSAU7410000
Chemical formulaC₁₁H₁₅N₅O₃S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO or DMF (25 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
Toxicity Irritant
ReferencesLee, S.H., and Cho, Y.D. 1998. Exp. Cell Res. 240, 282.
Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res. 51, 53.
Joy, A., et al. 1997. Oncogene 14, 171.
Riscoe, M.K., et al. 1984. Biochem. Pharmacol. 33, 3639.

Produits & Applications associés

Catégories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors